Linked Life Data

17633023

Source:http://linkedlifedata.com/resource/pubmed/id/17633023

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-7-17
pubmed:abstractText
The tumor necrosis factor receptor (TNFR) superfamily molecule CD40 is expressed by a wide variety of cell types following activation signals, and constitutively on B lymphocytes, macrophages, and dendritic cells. CD40 signals to cells stimulate kinase activation, gene expression, production of a antibody and a variety of cytokines, expression or upregulation of surface molecules, and protection or promotion of apoptosis. Initial steps in CD40-mediated signal cascades involve the interactions of CD40 with various members of the TNFR-associated factor (TRAF) family of cytoplasmic proteins. This review summarizes current understanding of the nature of these interactions, and how they induce and regulate CD40 functions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
597
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-51
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
TRAF proteins in CD40 signaling.
pubmed:affiliation
Department of Microbiology, Interdisciplinary Graduate Program in Immunology, University of Iowa and the Iowa City VAMC, Iowa City, Iowa 52242, USA. gail-bishop@uiowa.edu
pubmed:publicationType
Journal Article, Review