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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-8-7
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pubmed:abstractText |
To maintain immune homeostasis, the intestinal immune system has evolved redundant regulatory strategies. In this regard, the gut is home to a large number of regulatory T (T reg) cells, including the Foxp3(+) T reg cell. Therefore, we hypothesized that the gut environment preferentially supports extrathymic T reg cell development. We show that peripheral conversion of CD4(+) T cells to T reg cells occurs primarily in gut-associated lymphoid tissue (GALT) after oral exposure to antigen and in a lymphopenic environment. Dendritic cells (DCs) purified from the lamina propria (Lp; LpDCs) of the small intestine were found to promote a high level of T reg cell conversion relative to lymphoid organ-derived DCs. This enhanced conversion by LpDCs was dependent on TGF-beta and retinoic acid (RA), which is a vitamin A metabolite highly expressed in GALT. Together, these data demonstrate that the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-10978890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-11276200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-11290765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-11514600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-12626687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-12669023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-12840763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-12963696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-14609214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-14676299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-15100250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-15263027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-15485630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-15780990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-15795373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-15821737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-15937545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-16010704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-16121185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-16203863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-16216886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-16216890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-16220046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-16244650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-16287710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-16533884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-16648838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-17110582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-17307704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-17345581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-17620364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-2141319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-7520605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-7882170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-8514063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17620362-9670041
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
204
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1775-85
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17620362-Administration, Oral,
pubmed-meshheading:17620362-Animals,
pubmed-meshheading:17620362-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17620362-Cell Proliferation,
pubmed-meshheading:17620362-Dendritic Cells,
pubmed-meshheading:17620362-Forkhead Transcription Factors,
pubmed-meshheading:17620362-Immune System,
pubmed-meshheading:17620362-Intestine, Small,
pubmed-meshheading:17620362-Mice,
pubmed-meshheading:17620362-Mice, Inbred C57BL,
pubmed-meshheading:17620362-Mice, Transgenic,
pubmed-meshheading:17620362-Mucous Membrane,
pubmed-meshheading:17620362-Spleen,
pubmed-meshheading:17620362-T-Lymphocytes, Regulatory,
pubmed-meshheading:17620362-Tretinoin
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pubmed:year |
2007
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pubmed:articleTitle |
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.
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pubmed:affiliation |
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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