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pubmed-article:17617028pubmed:abstractTextThe enzyme tankyrase-1 (TNKS-1), a member of the growing family of poly(ADP-ribose) polymerases (PARPs), was identified as a component of the human telomeric complex. PARPs catalyze the formation of long chains of poly(ADP-ribose) onto protein acceptors using NAD(+) as a substrate. TNKS-1 interacts with the telomeric DNA-binding protein TTAGGG repeat-binding factor 1 (TRF1), which is a negative regulator of telomere length. TNKS-1 is a positive regulator of telomere elongation and its activity appears to be upregulated in some human cancers.lld:pubmed
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pubmed-article:17617028pubmed:articleTitleTankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience.lld:pubmed
pubmed-article:17617028pubmed:affiliationClinical Biochemistry Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy.lld:pubmed
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