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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2007-7-9
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pubmed:abstractText |
The enzyme tankyrase-1 (TNKS-1), a member of the growing family of poly(ADP-ribose) polymerases (PARPs), was identified as a component of the human telomeric complex. PARPs catalyze the formation of long chains of poly(ADP-ribose) onto protein acceptors using NAD(+) as a substrate. TNKS-1 interacts with the telomeric DNA-binding protein TTAGGG repeat-binding factor 1 (TRF1), which is a negative regulator of telomere length. TNKS-1 is a positive regulator of telomere elongation and its activity appears to be upregulated in some human cancers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1434-6621
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pubmed:author |
pubmed-author:Della MelinaAlessandroA,
pubmed-author:GelminiStefaniaS,
pubmed-author:GiannariniGianlucaG,
pubmed-author:MalentacchiFrancescaF,
pubmed-author:NicitaGiulioG,
pubmed-author:OrlandoClaudioC,
pubmed-author:PazzagliMarioM,
pubmed-author:QuattroneSilviaS,
pubmed-author:SelliCesareC,
pubmed-author:TravagliniFabrizioF,
pubmed-author:VillariDonataD
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
862-6
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pubmed:meshHeading |
pubmed-meshheading:17617028-Adult,
pubmed-meshheading:17617028-Aged,
pubmed-meshheading:17617028-Aged, 80 and over,
pubmed-meshheading:17617028-Female,
pubmed-meshheading:17617028-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17617028-Humans,
pubmed-meshheading:17617028-Male,
pubmed-meshheading:17617028-Middle Aged,
pubmed-meshheading:17617028-Neoplasm Recurrence, Local,
pubmed-meshheading:17617028-RNA, Messenger,
pubmed-meshheading:17617028-Tankyrases,
pubmed-meshheading:17617028-Telomere,
pubmed-meshheading:17617028-Urinary Bladder Neoplasms
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pubmed:year |
2007
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pubmed:articleTitle |
Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience.
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pubmed:affiliation |
Clinical Biochemistry Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy.
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pubmed:publicationType |
Journal Article
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