Linked Life Data

17609624

Source:http://linkedlifedata.com/resource/pubmed/id/17609624

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-7-4
pubmed:abstractText
Pilomyxoid astrocytoma (PmA) is a recently identified tumor type characteristically located in the hypothalamus and occurring in young children (<2 y). PmAs were formerly included in large series of pilocytic astrocytomas (PA) until it was realized in 1999 that this differing phenotype tended to manifest a more aggressive biologic course. PmA is defined by its pathologic features of a monomorphous architectural pattern, abundant myxoid background, and absence of features seen in classic PA. We present 4 histologically definite cases of PmA seen at our institution over a minimum 5-year follow-up time: one was rapidly fatal after initial treatment and 2 recurred during therapy. No singular neuroimaging feature can reliably diagnose PmA. However, PmAs tend to be solid, are more commonly necrotic and show extension of abnormal signal intensity into adjacent structures. Cysts, calcification, and perilesional edema are more common in classic PA. Serial neuroimaging in PmA shows early progression of predominantly solid, and later progression of predominantly cystic component. Radiologists should consider this diagnosis particularly in young children with hypothalamic tumors that lack the typical cystic appearance seen in PA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1077-4114
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
465-70
pubmed:dateRevised
2011-10-6
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Pilomyxoid astrocytoma: neuroimaging with clinicopathologic correlates in 4 cases followed over time.
pubmed:affiliation
Department of Radiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA. sirisha.komakula@uchsc.edu
pubmed:publicationType
Journal Article, Case Reports