| pubmed-article:17574421 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17574421 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:17574421 | lifeskim:mentions | umls-concept:C0005117 | lld:lifeskim |
| pubmed-article:17574421 | lifeskim:mentions | umls-concept:C1517336 | lld:lifeskim |
| pubmed-article:17574421 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:17574421 | lifeskim:mentions | umls-concept:C2003913 | lld:lifeskim |
| pubmed-article:17574421 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:17574421 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:17574421 | pubmed:dateCreated | 2007-6-26 | lld:pubmed |
| pubmed-article:17574421 | pubmed:abstractText | The interaction of berberine and its 9-substituted derivatives with human telomeric DNA d[G(3)(T(2)AG(3))(3)](telo21) has been investigated via CD spectroscopy, fluorescence spectroscopy, PCR-stop assay, competitive dialysis, and telomerase repeat amplification protocol (TRAP) assay. The results indicated that these semisynthesized compounds could induce and stabilize the formation of anti-parallel G-quadruplex of telomeric DNA in the presence or absence of metal cations. Compared with berberine, the 9-substituted derivatives exhibit stronger binding affinity with G-quadruplex and higher inhibitory activity for telomerase. Introduction of a side chain with proper length of methylene and terminal amino group to the 9-position of berberine would significantly strengthen the binding affinity with G-quadruplex, resulting in increasing inhibitory effects on the amplification of telo21 DNA and on the telomerase activity. | lld:pubmed |
| pubmed-article:17574421 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17574421 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17574421 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17574421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17574421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17574421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17574421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17574421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17574421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17574421 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17574421 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17574421 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:17574421 | pubmed:author | pubmed-author:WongKwok-YinK... | lld:pubmed |
| pubmed-article:17574421 | pubmed:author | pubmed-author:LuYu-JingYJ | lld:pubmed |
| pubmed-article:17574421 | pubmed:author | pubmed-author:GuLian-QuanLQ | lld:pubmed |
| pubmed-article:17574421 | pubmed:author | pubmed-author:HuangZhi-ShuZ... | lld:pubmed |
| pubmed-article:17574421 | pubmed:author | pubmed-author:ZhouJin-LinJL | lld:pubmed |
| pubmed-article:17574421 | pubmed:author | pubmed-author:OuTian-MiaoTM | lld:pubmed |
| pubmed-article:17574421 | pubmed:author | pubmed-author:HuangYing-YuY... | lld:pubmed |
| pubmed-article:17574421 | pubmed:author | pubmed-author:ZhangWan-JinW... | lld:pubmed |
| pubmed-article:17574421 | pubmed:author | pubmed-author:WuWei-BinWB | lld:pubmed |
| pubmed-article:17574421 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17574421 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17574421 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:17574421 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17574421 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17574421 | pubmed:pagination | 5493-501 | lld:pubmed |
| pubmed-article:17574421 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:meshHeading | pubmed-meshheading:17574421... | lld:pubmed |
| pubmed-article:17574421 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17574421 | pubmed:articleTitle | 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA. | lld:pubmed |
| pubmed-article:17574421 | pubmed:affiliation | School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510275, People's Republic of China. | lld:pubmed |
| pubmed-article:17574421 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17574421 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17574421 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17574421 | lld:pubmed |
