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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-6-11
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pubmed:abstractText |
Epidermal growth factor receptor (EGFR) stimulation enhances intestinal adaptation after massive small bowel resection (SBR), measured by taller villi, deeper crypts, and augmented enterocyte proliferation. Min mice with constitutively active beta-catenin signaling demonstrate enhanced villus growth after SBR, suggesting a role for the Wnt pathway during adaptation. Because there is crosstalk between EGFR signaling and the Wnt pathway, we hypothesized that beta-catenin is modulated by EGFR-induced enterocyte proliferation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases, Renilla,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1531-5037
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
981-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17560206-Active Transport, Cell Nucleus,
pubmed-meshheading:17560206-Adaptation, Physiological,
pubmed-meshheading:17560206-Animals,
pubmed-meshheading:17560206-Cell Division,
pubmed-meshheading:17560206-Cells, Cultured,
pubmed-meshheading:17560206-Cyclin D,
pubmed-meshheading:17560206-Cyclins,
pubmed-meshheading:17560206-Cytoplasm,
pubmed-meshheading:17560206-Enterocytes,
pubmed-meshheading:17560206-Epidermal Growth Factor,
pubmed-meshheading:17560206-Gene Expression Profiling,
pubmed-meshheading:17560206-Genes, Reporter,
pubmed-meshheading:17560206-Genes, myc,
pubmed-meshheading:17560206-Intestine, Small,
pubmed-meshheading:17560206-Luciferases, Renilla,
pubmed-meshheading:17560206-Male,
pubmed-meshheading:17560206-Mice,
pubmed-meshheading:17560206-Mice, Inbred C57BL,
pubmed-meshheading:17560206-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:17560206-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:17560206-RNA, Messenger,
pubmed-meshheading:17560206-Rats,
pubmed-meshheading:17560206-Rats, Sprague-Dawley,
pubmed-meshheading:17560206-Receptor, Epidermal Growth Factor,
pubmed-meshheading:17560206-Short Bowel Syndrome,
pubmed-meshheading:17560206-Signal Transduction,
pubmed-meshheading:17560206-Transcription, Genetic,
pubmed-meshheading:17560206-Transfection,
pubmed-meshheading:17560206-Wnt Proteins,
pubmed-meshheading:17560206-beta Catenin
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pubmed:year |
2007
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pubmed:articleTitle |
Epidermal growth factor receptor-directed enterocyte proliferation does not induce Wnt pathway transcription.
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pubmed:affiliation |
Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA.
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pubmed:publicationType |
Journal Article
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