Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
25
pubmed:dateCreated
2007-6-20
pubmed:abstractText
The role of the tumor suppressor retinoblastoma protein (pRb) has been firmly established in the control of cell cycle, apoptosis, and differentiation. Recently, it was demonstrated that lack of pRb promotes a switch from white to brown adipocyte differentiation in vitro. We used the Cre-Lox system to specifically inactivate pRb in adult adipose tissue. Under a high-fat diet, pRb-deficient (pRb(ad-/-)) mice failed to gain weight because of increased energy expenditure. This protection against weight gain was caused by the activation of mitochondrial activity in white and brown fat as evidenced by histologic, electron microscopic, and gene expression studies. Moreover, pRb(-/-) mouse embryonic fibroblasts displayed higher proliferation and apoptosis rates than pRb(+/+) mouse embryonic fibroblasts, which could contribute to the altered white adipose tissue morphology. Taken together, our data support a direct role of pRb in adipocyte cell fate determination in vivo and suggest that pRb could serve as a potential therapeutic target to trigger mitochondrial activation in white adipose tissue and brown adipose tissue, favoring an increase in energy expenditure and subsequent weight loss.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-10430085, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-10467224, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-10498881, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-10630640, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-10783170, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-10995476, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-11134524, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-11207048, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-11306495, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-11545733, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-11696583, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-12479814, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-12507421, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-12563312, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-12588810, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-12833141, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-1323843, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-1406932, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-1406933, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-1406937, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-14645521, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-15024128, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-15100410, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-15155905, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-15306821, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-15669057, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-16271529, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-16400329, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-16839885, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-17112576, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-7479022, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-8551611, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-8946919, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-9092557, http://linkedlifedata.com/resource/pubmed/commentcorrection/17556545-9529602
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10703-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.
pubmed:affiliation
Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Université Louis Pasteur, 1 Rue Laurent Fries, BP 10142, 67404 Illkirch, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural