Linked Life Data

1755030

Source:http://linkedlifedata.com/resource/pubmed/id/1755030

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
1992-1-29
pubmed:abstractText
Cynomolgus monkeys showed no measurable adverse effects following inhalation of 500 ppm dimethylformamide (DMF), 6 h/d, 5 d/wk, for 2 weeks either when exposed whole-body or head-only (one monkey per exposure route). Measurement of DMF concentrations into and out of the head-only exposure unit along with measurement of the tidal volume suggest that DMF absorption by the respiratory tract is approximately 100% at a concentration of 500 ppm. Plasma samples taken 1/2 to 18 h after the first exposure show DMF AUC values which were 3 times higher in the monkey exposed by whole-body, indicating considerable absorption by non-inhalation route(s). The same comparison of plasma samples taken following the final (10th) exposure similarly had a 6-times DMF AUC value for the monkey exposed by whole-body. From this study it is apparent that the practice of avoiding dermal contact with DMF is important in reducing the likelihood of producing DMF-induced injury in the workplace.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0378-4274
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
229-37
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Ten-day repeated-exposure inhalation study of dimethylformamide (DMF) in cynomolgus monkeys.
pubmed:affiliation
Du Pont, Haskell Laboratory for Toxicology and Industrial Medicine, Newark, DE 19714.
pubmed:publicationType
Journal Article