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rdf:type |
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lifeskim:mentions |
umls-concept:C0000970,
umls-concept:C0022885,
umls-concept:C0034656,
umls-concept:C0205054,
umls-concept:C0392366,
umls-concept:C0439208,
umls-concept:C0439228,
umls-concept:C0687725,
umls-concept:C1280500,
umls-concept:C1707491,
umls-concept:C2603343
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pubmed:dateCreated |
2007-6-22
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pubmed:abstractText |
Hepatic failure has been associated with reported therapeutic use of acetaminophen by alcoholic patients. The highest risk period for alcoholic patients is immediately after discontinuation of alcohol intake. This period exhibits the largest increase in CYP2E1 induction and lowest glutathione levels. Our hypothesis was that common liver tests would be unaffected by administration of the maximum recommended daily dosage of acetaminophen for 3 consecutive days to newly-abstinent alcoholic subjects.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-10781624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-10890286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-11319580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-11575982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-11790213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-11804663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-12020194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-12020195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-12236853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-16317692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-16481640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-16530510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-16820551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-1687856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-16950959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-18212776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-2052056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-2281334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-3197987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-3511825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-3946982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-4416585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-6128016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-6134146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-6801515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-6861588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-7625570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-7657281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-8123199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-8428720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-8437134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-8841146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-8946988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537264-9177503
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1741-7015
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17537264-Acetaminophen,
pubmed-meshheading:17537264-Adolescent,
pubmed-meshheading:17537264-Adult,
pubmed-meshheading:17537264-Alanine Transaminase,
pubmed-meshheading:17537264-Alcoholism,
pubmed-meshheading:17537264-Analgesics, Non-Narcotic,
pubmed-meshheading:17537264-Aspartate Aminotransferases,
pubmed-meshheading:17537264-Bilirubin,
pubmed-meshheading:17537264-Female,
pubmed-meshheading:17537264-Fever,
pubmed-meshheading:17537264-Glutathione,
pubmed-meshheading:17537264-Humans,
pubmed-meshheading:17537264-International Normalized Ratio,
pubmed-meshheading:17537264-Liver Diseases, Alcoholic,
pubmed-meshheading:17537264-Male,
pubmed-meshheading:17537264-Middle Aged,
pubmed-meshheading:17537264-Pain,
pubmed-meshheading:17537264-Risk Assessment,
pubmed-meshheading:17537264-Temperance
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pubmed:year |
2007
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pubmed:articleTitle |
The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.
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pubmed:affiliation |
Rocky Mountain Poison & Drug Center, Denver Health, Denver, CO, USA. ekuffner@mccus.jnj.com
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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