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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
8
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pubmed:dateCreated |
2007-8-7
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pubmed:abstractText |
A recent large-scale analysis of nonsynonymous coding polymorphisms showed strong evidence that an alanine to threonine amino acid change at codon 946 of the interferon-induced helicase (IFIH1) gene (SNP ID rs1990760) was associated with type 1 diabetes. Previous investigations have also demonstrated that an intronic polymorphism (termed PD1.3; SNP ID rs11568821) in the programmed cell death (PDCD1) gene was associated with systemic lupus erythematosus and rheumatoid arthritis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-972X
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pubmed:author |
pubmed-author:CheethamTimothy DTD,
pubmed-author:CordellHeather JHJ,
pubmed-author:DaviesJocelynJ,
pubmed-author:DonaldsonPeter TPT,
pubmed-author:JamesR AndrewRA,
pubmed-author:OwenCatherine JCJ,
pubmed-author:PearceSimon H SSH,
pubmed-author:PerrosPetrosP,
pubmed-author:QuintonRichardR,
pubmed-author:SutherlandAlisonA,
pubmed-author:VaikkakaraSureshS,
pubmed-author:WalkerChristineC
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pubmed:issnType |
Print
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pubmed:volume |
92
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3338-41
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17535987-Adult,
pubmed-meshheading:17535987-Alleles,
pubmed-meshheading:17535987-Cohort Studies,
pubmed-meshheading:17535987-DEAD-box RNA Helicases,
pubmed-meshheading:17535987-Female,
pubmed-meshheading:17535987-Genotype,
pubmed-meshheading:17535987-Graves Disease,
pubmed-meshheading:17535987-Humans,
pubmed-meshheading:17535987-Male,
pubmed-meshheading:17535987-Odds Ratio,
pubmed-meshheading:17535987-Polymorphism, Genetic,
pubmed-meshheading:17535987-Polymorphism, Single Nucleotide
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pubmed:year |
2007
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pubmed:articleTitle |
Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility.
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pubmed:affiliation |
Institute of Human Genetics, Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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