Linked Life Data

17525355

Source:http://linkedlifedata.com/resource/pubmed/id/17525355

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-5-25
pubmed:abstractText
Little is known about the genetic background of keratocystic odontogenic tumors (KCOT, odontogenic keratocysts). Our aim was to characterize genomic aberrations in sporadic KCOT using cDNA-expression arrays and array-comparative genomic hybridization. For cDNA-expression arrays, 10 KCOT specimens and 20 fetal tooth germs were studied. Quantitative real-time reverse-transcription/polymerase chain-reaction and immunohistochemical studies were also undertaken. Several genes were over-expressed in 12q13, including cytokeratin 6B (KRT6B) ( approximately 10-fold), epidermal growth factor receptor ERBB3 (approximately 4.7-fold), and glioma-associated oncogene homologue 1 (GLI1) (approximately 5- to 12-fold). One amplicon (approximately 0.7 Mega base pairs [Mbp]), covering several genes involved in the regulation of cell growth, was found in 12q13.2. Deletions were found in 3q13.1, 5p14.3, and 7q31.3, including the cell-adhesion-related gene cadherin 18 (CDH18) and leukocyte cell adhesion molecule (ALCAM, MEMD). Over-expressed and amplified genes in 12q13, also reported in several other tumors and cell lines, may contribute to the persistent growth characteristics of KCOT.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-0345
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
544-9
pubmed:dateRevised
2007-7-21
pubmed:meshHeading
pubmed-meshheading:17525355-Activated-Leukocyte Cell Adhesion Molecule, pubmed-meshheading:17525355-Cadherins, pubmed-meshheading:17525355-Chromosome Aberrations, pubmed-meshheading:17525355-Chromosomes, Human, Pair 12, pubmed-meshheading:17525355-DNA, pubmed-meshheading:17525355-Gene Deletion, pubmed-meshheading:17525355-Gene Expression Regulation, pubmed-meshheading:17525355-Genes, erbB-1, pubmed-meshheading:17525355-Humans, pubmed-meshheading:17525355-Immunohistochemistry, pubmed-meshheading:17525355-Keratin-6, pubmed-meshheading:17525355-Nucleic Acid Hybridization, pubmed-meshheading:17525355-Odontogenic Cysts, pubmed-meshheading:17525355-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:17525355-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:17525355-Tooth Germ, pubmed-meshheading:17525355-Transcription Factors
pubmed:year
2007
pubmed:articleTitle
Genetic changes in sporadic keratocystic odontogenic tumors (odontogenic keratocysts).
pubmed:affiliation
Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, FIN-20520 Turku, Finland. heikinhe@netlife.fi
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't