| pubmed-article:17504937 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17504937 | lifeskim:mentions | umls-concept:C1511002 | lld:lifeskim |
| pubmed-article:17504937 | lifeskim:mentions | umls-concept:C1421565 | lld:lifeskim |
| pubmed-article:17504937 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:17504937 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:17504937 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:17504937 | pubmed:dateCreated | 2007-5-16 | lld:pubmed |
| pubmed-article:17504937 | pubmed:abstractText | The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the immunoglobulin heavy-chain (IgH) locus and a block in the progenitor-B-to-precursor-B-cell transition, which was partially rescued by a prerearranged IgH transgene. Three-dimensional DNA fluorescence in situ hybridization analysis revealed an important function for YY1 in IgH locus contraction, a process indispensable for distal V(H) to D(H)J(H) recombination. We provide evidence that YY1 binds the intronic Ei mu enhancer within the IgH locus, consistent with a direct role for YY1 in V(H)D(H)J(H) recombination. These findings identified YY1 as a critical regulator of early B-cell development. | lld:pubmed |
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| pubmed-article:17504937 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17504937 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17504937 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17504937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17504937 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17504937 | pubmed:month | May | lld:pubmed |
| pubmed-article:17504937 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:17504937 | pubmed:author | pubmed-author:ShiYangY | lld:pubmed |
| pubmed-article:17504937 | pubmed:author | pubmed-author:PelandaRobert... | lld:pubmed |
| pubmed-article:17504937 | pubmed:author | pubmed-author:HobeikaEliasE | lld:pubmed |
| pubmed-article:17504937 | pubmed:author | pubmed-author:RethMichaelM | lld:pubmed |
| pubmed-article:17504937 | pubmed:author | pubmed-author:RajewskyKlaus... | lld:pubmed |
| pubmed-article:17504937 | pubmed:author | pubmed-author:ShiYujiangY | lld:pubmed |
| pubmed-article:17504937 | pubmed:author | pubmed-author:Schmidt-Suppr... | lld:pubmed |
| pubmed-article:17504937 | pubmed:author | pubmed-author:LiuHuifeiH | lld:pubmed |
| pubmed-article:17504937 | pubmed:author | pubmed-author:BartenevaNata... | lld:pubmed |
| pubmed-article:17504937 | pubmed:author | pubmed-author:JumaaHassanH | lld:pubmed |
| pubmed-article:17504937 | pubmed:author | pubmed-author:SkokJaneJ | lld:pubmed |
| pubmed-article:17504937 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17504937 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17504937 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:17504937 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17504937 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17504937 | pubmed:pagination | 1179-89 | lld:pubmed |
| pubmed-article:17504937 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17504937 | pubmed:meshHeading | pubmed-meshheading:17504937... | lld:pubmed |
