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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-5-14
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pubmed:abstractText |
The peripheral chemoreceptors are the dominant reflex mechanism responsible for the rise in ventilation and muscle sympathetic nerve activity (MSNA) in response to hypoxia. Animal studies have suggested that endothelin (ET) plays an important role in chemosensitivity. Moreover, several human clinical conditions in which circulating ET levels are increased are accompanied by enhanced chemoreflex sensitivity. Whether ET plays a role in normal human chemosensitivity is unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0012-3692
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1467-72
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17494795-Acute Disease,
pubmed-meshheading:17494795-Adult,
pubmed-meshheading:17494795-Anoxia,
pubmed-meshheading:17494795-Apnea,
pubmed-meshheading:17494795-Blood Pressure,
pubmed-meshheading:17494795-Chemoreceptor Cells,
pubmed-meshheading:17494795-Cross-Over Studies,
pubmed-meshheading:17494795-Double-Blind Method,
pubmed-meshheading:17494795-Endothelins,
pubmed-meshheading:17494795-Heart Rate,
pubmed-meshheading:17494795-Humans,
pubmed-meshheading:17494795-Male,
pubmed-meshheading:17494795-Muscles,
pubmed-meshheading:17494795-Pulmonary Ventilation,
pubmed-meshheading:17494795-Receptors, Endothelin,
pubmed-meshheading:17494795-Sulfonamides,
pubmed-meshheading:17494795-Sympathetic Nervous System
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pubmed:year |
2007
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pubmed:articleTitle |
Does endothelin play a role in chemoreception during acute hypoxia in normal men?
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pubmed:affiliation |
Department of Cardiology, Erasme University Hospital, 808 Lennik Road, B-1070 Brussels, Belgium. marko.gujic@ulb.ac.be
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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