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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-4-26
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pubmed:abstractText |
Proliferative vitreoretinopathy (PVR) is a disorder characterized by the formation of cellular membranes on both surfaces of the retina and within the vitreous cavity. It occurs in 5% to 10% of patients who undergo retinal reattachment surgery. In the rabbit model of the disease, the platelet-derived growth factor alpha receptor (PDGFRalpha) is dramatically more capable of promoting PVR than is closely related PDGFRbeta. To test the ligand hypothesis (i.e., that this phenomenon can be explained by a predominance of PDGFRalpha-specific ligands) this study was conducted to determine the profile of PDGF ligands expressed by cells that induce PVR and in the vitreous of rabbits that have PVR. In addition, we examined which PDGF isoforms were present in the vitreous of patients with PVR, to assess the relevance of the rabbit model to the clinical setting.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2335-42
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pubmed:dateRevised |
2011-1-12
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pubmed:meshHeading |
pubmed-meshheading:17460299-Animals,
pubmed-meshheading:17460299-Blotting, Western,
pubmed-meshheading:17460299-Cell Culture Techniques,
pubmed-meshheading:17460299-Conjunctiva,
pubmed-meshheading:17460299-Disease Models, Animal,
pubmed-meshheading:17460299-Embryo, Mammalian,
pubmed-meshheading:17460299-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17460299-Fibroblasts,
pubmed-meshheading:17460299-Humans,
pubmed-meshheading:17460299-Immunoblotting,
pubmed-meshheading:17460299-Ligands,
pubmed-meshheading:17460299-Lymphokines,
pubmed-meshheading:17460299-Mice,
pubmed-meshheading:17460299-Mice, Knockout,
pubmed-meshheading:17460299-Pigment Epithelium of Eye,
pubmed-meshheading:17460299-Platelet-Derived Growth Factor,
pubmed-meshheading:17460299-Protein Isoforms,
pubmed-meshheading:17460299-Rabbits,
pubmed-meshheading:17460299-Receptor, Platelet-Derived Growth Factor alpha,
pubmed-meshheading:17460299-Receptor, Platelet-Derived Growth Factor beta,
pubmed-meshheading:17460299-Vitreoretinopathy, Proliferative,
pubmed-meshheading:17460299-Vitreous Body
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pubmed:year |
2007
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pubmed:articleTitle |
A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy.
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pubmed:affiliation |
The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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