| pubmed-article:17457544 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17457544 | lifeskim:mentions | umls-concept:C0001774 | lld:lifeskim |
| pubmed-article:17457544 | lifeskim:mentions | umls-concept:C1051043 | lld:lifeskim |
| pubmed-article:17457544 | lifeskim:mentions | umls-concept:C1093837 | lld:lifeskim |
| pubmed-article:17457544 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:17457544 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17457544 | lifeskim:mentions | umls-concept:C1979935 | lld:lifeskim |
| pubmed-article:17457544 | lifeskim:mentions | umls-concept:C2936720 | lld:lifeskim |
| pubmed-article:17457544 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17457544 | pubmed:dateCreated | 2007-6-22 | lld:pubmed |
| pubmed-article:17457544 | pubmed:abstractText | The anti-diabetic activities of the exopolysaccharides (EPS) produced by submerged mycelial culture of two different mushrooms, Tremella fuciformis and Phellinus baumii, in ob/ob mice were investigated. All the animals were randomly divided into three groups with seven animals in each group: The control group received 0.9% NaCl solution; the diabetic groups were treated with EPS from T. fuciformis (Tf EPS) and P. baumii (Pb EPS) at the level of 200 mg/kg body weight using an oral zoned daily for 52 days. The plasma glucose levels in the EPS-fed mice were substantially reduced by about 52% (Tf EPS) and 32% (Pb EPS), respectively, as compared to control mice. The results of oral glucose tolerance test (OGTT) revealed that both EPS-fed groups significantly increased the glucose disposal after 52 days of EPS treatments. Furthermore, higher food efficiency ratios and reduced blood triglyceride levels were observed in the EPS-treated groups. Because peroxisome proliferator-activated receptor gamma (PPAR-gamma) is indeed a key regulator of insulin action, we investigated the expression pattern of adipose tissue PPAR-gamma messenger RNA (mRNA) and plasma levels of PPAR-gamma. It was revealed that PPAR-gamma was significantly activated in response to EPS treatments. The results suggested that both EPS exhibited considerable hypoglycemic effect and improved insulin sensitivity possibly through regulating PPAR-gamma-mediated lipid metabolism. Our results indicated that two mushroom-derived EPS might be developed as potential oral hypoglycemic agents or functional foods for the management of non-insulin-dependent diabetes mellitus. | lld:pubmed |
| pubmed-article:17457544 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17457544 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17457544 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17457544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17457544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17457544 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17457544 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17457544 | pubmed:issn | 0175-7598 | lld:pubmed |
| pubmed-article:17457544 | pubmed:author | pubmed-author:HwangHye... | lld:pubmed |
| pubmed-article:17457544 | pubmed:author | pubmed-author:KimSang WooSW | lld:pubmed |
| pubmed-article:17457544 | pubmed:author | pubmed-author:YunJong WonJW | lld:pubmed |
| pubmed-article:17457544 | pubmed:author | pubmed-author:ChoiJang... | lld:pubmed |
| pubmed-article:17457544 | pubmed:author | pubmed-author:ChoEun JaeEJ | lld:pubmed |
| pubmed-article:17457544 | pubmed:author | pubmed-author:OhJung... | lld:pubmed |
| pubmed-article:17457544 | pubmed:author | pubmed-author:BaeSong... | lld:pubmed |
| pubmed-article:17457544 | pubmed:author | pubmed-author:BaekYu MiYM | lld:pubmed |
| pubmed-article:17457544 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17457544 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:17457544 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17457544 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17457544 | pubmed:pagination | 1257-65 | lld:pubmed |
| pubmed-article:17457544 | pubmed:meshHeading | pubmed-meshheading:17457544... | lld:pubmed |
| pubmed-article:17457544 | pubmed:meshHeading | pubmed-meshheading:17457544... | lld:pubmed |
| pubmed-article:17457544 | pubmed:meshHeading | pubmed-meshheading:17457544... | lld:pubmed |
| pubmed-article:17457544 | pubmed:meshHeading | pubmed-meshheading:17457544... | lld:pubmed |
| pubmed-article:17457544 | pubmed:meshHeading | pubmed-meshheading:17457544... | lld:pubmed |
| pubmed-article:17457544 | pubmed:meshHeading | pubmed-meshheading:17457544... | lld:pubmed |
| pubmed-article:17457544 | pubmed:meshHeading | pubmed-meshheading:17457544... | lld:pubmed |
| pubmed-article:17457544 | pubmed:meshHeading | pubmed-meshheading:17457544... | lld:pubmed |
| pubmed-article:17457544 | pubmed:meshHeading | pubmed-meshheading:17457544... | lld:pubmed |
| pubmed-article:17457544 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17457544 | pubmed:articleTitle | Hypoglycemic effects of exopolysaccharides produced by mycelial cultures of two different mushrooms Tremella fuciformis and Phellinus baumii in ob/ob mice. | lld:pubmed |
| pubmed-article:17457544 | pubmed:affiliation | Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk 712-714, Republic of Korea. | lld:pubmed |
| pubmed-article:17457544 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17457544 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
