| pubmed-article:17446209 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17446209 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17446209 | lifeskim:mentions | umls-concept:C0599840 | lld:lifeskim |
| pubmed-article:17446209 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17446209 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:17446209 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:17446209 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17446209 | pubmed:dateCreated | 2007-5-3 | lld:pubmed |
| pubmed-article:17446209 | pubmed:abstractText | Human Vgamma2Vdelta2 T cells are stimulated by prenyl pyrophosphates, such as isopentenyl pyrophosphate (IPP), and play important roles in mediating immunity against microbial pathogens and have potent anti-tumor activity. (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) has been identified as a metabolite in the 2-C-methyl-D-erythritol-4 phosphate (MEP) pathway for isoprenoid biosynthesis that is used by many bacteria and protozoan parasites. We find that HMBPP is the major Vgamma2Vdelta2 T-cell antigen for many bacteria, including Mycobacterium tuberculosis, Yersinia enterocolitica and Escherichia coli. HMBPP was a 30 000-fold more potent antigen than IPP. Using mutant bacteria, we show that bacterial antigen levels for Vgamma2Vdelta2 T cells are controlled by MEP pathway enzymes and find no evidence for the production of 3-formyl-1-butyl pyrophosphate. Moreover, HMBPP reactivity required only germ line-encoded Vgamma2Vdelta2 TCR elements and is present at birth. Importantly, we show that bacterial HMBPP levels correlated with their ability to expand Vgamma2Vdelta2 T cells in vivo upon engraftment into severe combined immunodeficiency-beige mice. Thus, the production of HMBPP by a microbial-specific isoprenoid pathway plays a major role in determining whether bacteria will stimulate Vgamma2Vdelta2 T cells in vivo. This preferential stimulation by a common microbial isoprenoid metabolite allows Vgamma2Vdelta2 T cells to respond to a broad array of pathogens using this pathway. | lld:pubmed |
| pubmed-article:17446209 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17446209 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17446209 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17446209 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17446209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17446209 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17446209 | pubmed:month | May | lld:pubmed |
| pubmed-article:17446209 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:17446209 | pubmed:author | pubmed-author:WangHongH | lld:pubmed |
| pubmed-article:17446209 | pubmed:author | pubmed-author:KuzuyamaTomoh... | lld:pubmed |
| pubmed-article:17446209 | pubmed:author | pubmed-author:Pasa-TolicLji... | lld:pubmed |
| pubmed-article:17446209 | pubmed:author | pubmed-author:MoritaCraig... | lld:pubmed |
| pubmed-article:17446209 | pubmed:author | pubmed-author:Märker-Herman... | lld:pubmed |
| pubmed-article:17446209 | pubmed:author | pubmed-author:GinerJosé-Lui... | lld:pubmed |
| pubmed-article:17446209 | pubmed:author | pubmed-author:LeeHoi KHK | lld:pubmed |
| pubmed-article:17446209 | pubmed:author | pubmed-author:NievesEdwardE | lld:pubmed |
| pubmed-article:17446209 | pubmed:author | pubmed-author:JinChenggangC | lld:pubmed |
| pubmed-article:17446209 | pubmed:author | pubmed-author:RakerAmy MAM | lld:pubmed |
| pubmed-article:17446209 | pubmed:author | pubmed-author:PuanKia-JooKJ | lld:pubmed |
| pubmed-article:17446209 | pubmed:author | pubmed-author:SarikondaGhan... | lld:pubmed |
| pubmed-article:17446209 | pubmed:author | pubmed-author:SamuelsonMega... | lld:pubmed |
| pubmed-article:17446209 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17446209 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:17446209 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17446209 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17446209 | pubmed:pagination | 657-73 | lld:pubmed |
| pubmed-article:17446209 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
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| pubmed-article:17446209 | pubmed:meshHeading | pubmed-meshheading:17446209... | lld:pubmed |
| pubmed-article:17446209 | pubmed:meshHeading | pubmed-meshheading:17446209... | lld:pubmed |
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| pubmed-article:17446209 | pubmed:meshHeading | pubmed-meshheading:17446209... | lld:pubmed |
| pubmed-article:17446209 | pubmed:meshHeading | pubmed-meshheading:17446209... | lld:pubmed |
| pubmed-article:17446209 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17446209 | pubmed:articleTitle | Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. | lld:pubmed |
| pubmed-article:17446209 | pubmed:affiliation | Division of Rheumatology, Department of Internal Medicine and the Interdisciplinary Graduate Program in Immunology, University of Iowa College of Medicine, EMRB 400F, Iowa City, IA 52242, USA. | lld:pubmed |
| pubmed-article:17446209 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17446209 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:17446209 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17446209 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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