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pubmed-article:17444626pubmed:abstractTextA series of N-substituted-quinolinone-3-aminoamides and their hybrids containing the alpha-lipoic acid functionality were designed and synthesized as potential bifunctional agents combining antioxidant and anti-inflammatory activity. The new compounds were evaluated for their antioxidant activity and for their ability to inhibit in vitro lipoxygenase as well as for their anti-inflammatory activity in vivo. In general, the derivatives were found to be potent antioxidant or anti-inflammatory agents. The results are discussed in terms of structure-activity relationships and an attempt is made to define the structural features required for activity.lld:pubmed
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pubmed-article:17444626pubmed:articleTitleDesign and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents.lld:pubmed
pubmed-article:17444626pubmed:affiliationLaboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Zorgafou Campus, GR 157 73, Athens, Greece. adetsi@chemeng.ntua.grlld:pubmed
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