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rdf:type |
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lifeskim:mentions |
umls-concept:C0002395,
umls-concept:C0012655,
umls-concept:C0017337,
umls-concept:C0021641,
umls-concept:C0037083,
umls-concept:C0166417,
umls-concept:C0332120,
umls-concept:C1418371,
umls-concept:C1420315,
umls-concept:C1708726,
umls-concept:C1710082,
umls-concept:C2717881
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pubmed:issue |
4
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pubmed:dateCreated |
2007-5-30
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pubmed:abstractText |
Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes--PPARgamma, SOS2, and PCK1--with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoenolpyruvate Carboxykinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Inwardly...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/SOS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Son of Sevenless Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/sulfonylurea receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1552-4841
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2007 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
144B
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
508-16
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17440948-ATP-Binding Cassette Transporters,
pubmed-meshheading:17440948-Age of Onset,
pubmed-meshheading:17440948-Aged,
pubmed-meshheading:17440948-Aged, 80 and over,
pubmed-meshheading:17440948-Alzheimer Disease,
pubmed-meshheading:17440948-Female,
pubmed-meshheading:17440948-Gene Frequency,
pubmed-meshheading:17440948-Genetic Predisposition to Disease,
pubmed-meshheading:17440948-Great Britain,
pubmed-meshheading:17440948-Haplotypes,
pubmed-meshheading:17440948-Humans,
pubmed-meshheading:17440948-Insulin,
pubmed-meshheading:17440948-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:17440948-Male,
pubmed-meshheading:17440948-PPAR gamma,
pubmed-meshheading:17440948-Phosphoenolpyruvate Carboxykinase (GTP),
pubmed-meshheading:17440948-Polymorphism, Single Nucleotide,
pubmed-meshheading:17440948-Potassium Channels,
pubmed-meshheading:17440948-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:17440948-Receptors, Drug,
pubmed-meshheading:17440948-Sex Characteristics,
pubmed-meshheading:17440948-Signal Transduction,
pubmed-meshheading:17440948-Son of Sevenless Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci.
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pubmed:affiliation |
MRC Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, Kings College London, Denmark Hill, London, UK. G.Hamilton@iop.kcl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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