Linked Life Data

1741993

Source:http://linkedlifedata.com/resource/pubmed/id/1741993

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10 Pt 2
pubmed:dateCreated
1992-1-16
pubmed:abstractText
In experiments on rats, the physiological effects of the antihypertensive humoral system of the renal medulla were explored. We studied the parameters of blood pressure, heart rate, efferent sympathetic nervous activity to the splanchnic region, diuresis and natriuresis. The experimental situations included studies on normotensive rats, injected with extracted renomedullary lipids (medullipin), and normotensive rats extracorporally cross-perfusing an isolated kidney at increased pressure levels, to explore the release of renomedullary depressor substances. Spontaneously hyperactive rat (SHR) kidneys were also cross-perfused to study whether the renomedullary mechanism was reset upwards in this type of primary hypertension. Finally, the acute pressure reductions caused by angiotensin converting enzyme (ACE)-inhibitors were studied in intact and chemically medullectomized (2-bromo-ethylamine hydrobromide) rats to explore whether they were at least in part dependent on an intact renal medulla. In normal kidneys the renomedullary depressor system was initiated already at physiological pressure levels (at or above 100 mm Hg), causing the following humorally induced response pattern: the blood pressure fall was associated with decreases in both heart rate and sympathetic activity, while diuresis and natriuresis increased. In SHR kidneys, perfusion pressure had to be raised between 200 and 250 mm Hg before this depressor pattern was activated, revealing an "upward renomedullary resetting" well beyond the prevailing SHR blood pressure. The acute blood pressure decrease initiated in normotensive rats by an ACE-inhibitor (enalaprilat) was abolished in medullectomized rats, indicating an interaction between the renin-angiotensin and the renomedullary antihypertensive systems.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0895-7061
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
569S-574S
pubmed:dateRevised
2009-2-24
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Physiological effects of the humoral renomedullary antihypertensive system.
pubmed:affiliation
Department of Physiology, University of Göteborg, Sweden.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't