Source:http://linkedlifedata.com/resource/pubmed/id/17419055
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2007-6-4
|
| pubmed:abstractText |
A novel series of 6-substituted 4-sulfonyl-1,4-diazepane-2,5-diones were designed, synthesized and evaluated as human chymase inhibitors. Structure-activity relationship studies led to the identification of a potent inhibitor, (6S)-6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione, with an IC(50) of 0.027 microM.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3431-4
|
| pubmed:meshHeading |
pubmed-meshheading:17419055-Azepines,
pubmed-meshheading:17419055-Chymases,
pubmed-meshheading:17419055-Humans,
pubmed-meshheading:17419055-Inhibitory Concentration 50,
pubmed-meshheading:17419055-Models, Chemical,
pubmed-meshheading:17419055-Serine Proteinase Inhibitors,
pubmed-meshheading:17419055-Structure-Activity Relationship
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors.
|
| pubmed:affiliation |
Biomedical Research Laboratories, Daiichi Asubio Pharma Co., Ltd, 1-1-1 Wakayamadai Shimamoto-cho, Mishima-gun, Osaka 618-8513, Japan. tanaka.taisasku.fu@asubio.co.jp
|
| pubmed:publicationType |
Journal Article
|