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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-5-18
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pubmed:abstractText |
Angiogenesis is a critical step in tumor growth, progression, and metastasis. Soft tissue and bone sarcoma are resistant to most therapeutic approaches. Angiogenesis of these tumors may be an effective target. We hypothesized that we could inhibit tumor growth by targeting angiogenesis in a mouse model of sarcoma. We demonstrate in this report, using powerful color-coded fluorescent imageable tumor-host models, the onset of angiogenesis of these sarcomas and its inhibition.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
165-70
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:17418866-Animals,
pubmed-meshheading:17418866-Antibiotics, Antineoplastic,
pubmed-meshheading:17418866-Bone Neoplasms,
pubmed-meshheading:17418866-Cell Line, Tumor,
pubmed-meshheading:17418866-Cell Proliferation,
pubmed-meshheading:17418866-Doxorubicin,
pubmed-meshheading:17418866-Endothelium, Vascular,
pubmed-meshheading:17418866-Fibrosarcoma,
pubmed-meshheading:17418866-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17418866-Green Fluorescent Proteins,
pubmed-meshheading:17418866-Humans,
pubmed-meshheading:17418866-Intermediate Filament Proteins,
pubmed-meshheading:17418866-Luminescent Proteins,
pubmed-meshheading:17418866-Mice,
pubmed-meshheading:17418866-Mice, Nude,
pubmed-meshheading:17418866-Mice, Transgenic,
pubmed-meshheading:17418866-Microscopy, Fluorescence,
pubmed-meshheading:17418866-Neovascularization, Pathologic,
pubmed-meshheading:17418866-Nerve Tissue Proteins,
pubmed-meshheading:17418866-Regional Blood Flow,
pubmed-meshheading:17418866-Sarcoma
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pubmed:year |
2007
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pubmed:articleTitle |
Dual-color imaging of angiogenesis and its inhibition in bone and soft tissue sarcoma.
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pubmed:affiliation |
Department of Surgery, University of California San Diego, San Diego, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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