Source:http://linkedlifedata.com/resource/pubmed/id/17398188
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2007-4-2
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| pubmed:abstractText |
A history of renal insufficiency or increased creatinine level on admission is associated with poor outcomes in patients with acute coronary syndrome (ACS). This study sought to determine whether in-hospital worsening of renal function, either transient or sustained, is an independent risk factor for 6-month mortality in patients admitted with ACS. A total of 1,417 patients admitted with ACS from June 2000 to May 2003 were reviewed. Patients were classified into 3 groups. Group I included patients with an increase in creatinine during hospitalization of <or=0.5 mg/dl. Group II included patients with an increase in creatinine of >0.5 mg/dl that resolved by discharge. Group III included patients with an increase in creatinine of >0.5 mg/dl that did not resolve. The primary end point was 6-month mortality from any cause. Patients in groups II and III had higher 6-month mortality rates (27% and 23%, respectively; both p<0.001) compared with patients in group I (7.4%). After adjustment for known risk factors, a transient increase in creatinine remained a significant independent predictor of 6-month mortality (odds ratio 2.07, 95% confidence interval 1.14 to 3.76), although a sustained increase in creatinine showed a trend (odds ratio 1.58, 95% confidence interval 0.68 to 3.70). In conclusion, independent of a history of renal insufficiency or increased admission creatinine, in-hospital worsening of renal function is an important risk factor for 6-month mortality in patients admitted with ACS. Furthermore, return to baseline function by discharge does not protect against this risk. These findings have implications for management of these high-risk patients.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0002-9149
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
99
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
939-42
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:17398188-Acute Disease,
pubmed-meshheading:17398188-Aged,
pubmed-meshheading:17398188-Analysis of Variance,
pubmed-meshheading:17398188-Biological Markers,
pubmed-meshheading:17398188-Coronary Artery Disease,
pubmed-meshheading:17398188-Creatinine,
pubmed-meshheading:17398188-Female,
pubmed-meshheading:17398188-Follow-Up Studies,
pubmed-meshheading:17398188-Humans,
pubmed-meshheading:17398188-Kidney Function Tests,
pubmed-meshheading:17398188-Male,
pubmed-meshheading:17398188-Michigan,
pubmed-meshheading:17398188-Middle Aged,
pubmed-meshheading:17398188-Myocardial Infarction,
pubmed-meshheading:17398188-Patient Admission,
pubmed-meshheading:17398188-Predictive Value of Tests,
pubmed-meshheading:17398188-Prognosis,
pubmed-meshheading:17398188-Research Design,
pubmed-meshheading:17398188-Risk Factors,
pubmed-meshheading:17398188-Survival Analysis,
pubmed-meshheading:17398188-Syndrome,
pubmed-meshheading:17398188-Time Factors
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Prognostic value of transient and sustained increase in in-hospital creatinine on outcomes of patients admitted with acute coronary syndrome.
|
| pubmed:affiliation |
University of Michigan Hospital, Ann Arbor, Michigan, USA. raklatch@yahoo.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|