pubmed-article:17392506 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17392506 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
pubmed-article:17392506 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
pubmed-article:17392506 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
pubmed-article:17392506 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:17392506 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
pubmed-article:17392506 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
pubmed-article:17392506 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
pubmed-article:17392506 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
pubmed-article:17392506 | lifeskim:mentions | umls-concept:C0679006 | lld:lifeskim |
pubmed-article:17392506 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:17392506 | pubmed:dateCreated | 2007-6-20 | lld:pubmed |
pubmed-article:17392506 | pubmed:abstractText | Expression of the PD-1 receptor on T cells has been shown to provide an important inhibitory signal that down-modulates peripheral effector responses in normal tissues and tumors. Furthermore, PD-1 up-regulation on chronically activated T cells can maintain them in a partially reversible inactive state. The function of PD-1 in the very early stages of T-cell response to antigen in vivo has not been fully explored. In this study, we evaluate the role of PD-1 and its 2 B7 family ligands, B7-H1 (PD-L1) and B7-DC (PD-L2), in early fate decisions of CD8 T cells. We show that CD8 T cells specific for influenza hemagglutinin (HA) expressed as a self-antigen become functionally tolerized and express high levels of surface PD-1 by the time of their first cell division. Blockade of PD-1 or B7-H1, but not B7-DC, at the time of self-antigen encounter mitigates tolerance induction and results in CD8 T-cell differentiation into functional cytolytic T lymphocytes (CTLs). These findings demonstrate that, in addition to modulating effector functions in the periphery, B7-H1:PD-1 interactions regulate early T-cell-fate decisions. | lld:pubmed |
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pubmed-article:17392506 | pubmed:language | eng | lld:pubmed |
pubmed-article:17392506 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17392506 | pubmed:citationSubset | AIM | lld:pubmed |
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pubmed-article:17392506 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17392506 | pubmed:month | Jul | lld:pubmed |
pubmed-article:17392506 | pubmed:issn | 0006-4971 | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:ChenLiepingL | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:TuderRubin... | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:PardollDrew... | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:WhartenbyKath... | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:DrakeCharles... | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:ZhenLijieL | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:DubenskyThoma... | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:BrockstedtDir... | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:MarisCharles... | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:GrossoJoseph... | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:HipkissEdward... | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:FliesAndrew... | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:GoldbergMonic... | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:HarrisTimothy... | lld:pubmed |
pubmed-article:17392506 | pubmed:author | pubmed-author:GetnetDereseD | lld:pubmed |
pubmed-article:17392506 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17392506 | pubmed:day | 1 | lld:pubmed |
pubmed-article:17392506 | pubmed:volume | 110 | lld:pubmed |
pubmed-article:17392506 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17392506 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17392506 | pubmed:pagination | 186-92 | lld:pubmed |
pubmed-article:17392506 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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