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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-5-17
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pubmed:abstractText |
The Ovalbumin(257-264) CTL epitope on the major coat protein of the filamentous bacteriophage in different antigen formulations was displayed and the immune response in C57BL6/J mice studied. The display of single cytotoxic epitope on the surface of the virion is sufficient to induce priming and sustain long-term major histocompatibility complex class I restricted cytotoxic T lymphocytes response in vivo. The filamentous bacteriophage is a versatile carrier able to display simultaneously either single or multiple epitopes and can elicit a cellular response carrying very little peptide (<1.5 microg).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0928-8244
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-66
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17391361-Animals,
pubmed-meshheading:17391361-Bacteriophages,
pubmed-meshheading:17391361-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17391361-Egg Proteins,
pubmed-meshheading:17391361-Epitopes, T-Lymphocyte,
pubmed-meshheading:17391361-Female,
pubmed-meshheading:17391361-Lymphocyte Activation,
pubmed-meshheading:17391361-Mice,
pubmed-meshheading:17391361-Mice, Inbred BALB C,
pubmed-meshheading:17391361-Mice, Inbred C57BL,
pubmed-meshheading:17391361-Ovalbumin,
pubmed-meshheading:17391361-Peptide Fragments,
pubmed-meshheading:17391361-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:17391361-T-Lymphocytes, Helper-Inducer
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pubmed:year |
2007
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pubmed:articleTitle |
Phage display of a CTL epitope elicits a long-term in vivo cytotoxic response.
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pubmed:affiliation |
Institute of Genetics and Biophysics Adriano Buzzati Traverso, CNR, Naples, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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