Linked Life Data

17390042

Source:http://linkedlifedata.com/resource/pubmed/id/17390042

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-3-28
pubmed:abstractText
Among 13 patients with recurrent colorectal cancer (recurrence group: RG), immunohistochemical expression of Topo-1 was high in 4 patients (30.8%) and low in 9 patients (69.2%), while the non-recurrence group (N-RG) (n=8) showed high expression in 1 patient (12.5%) and low expression in 7 patients (87.5%) (NS). Regarding immunohistochemical expression of Bax/ERCC-1, high Bax/low ERCC-1 expression was observed in 6 patients (46.2%) from the RG and other patterns of expression were seen in 7 patients (53.8%), while high Bax/low ERCC-1 expression was observed in 4 patients (50.0%) from the N-RG and other patterns were found in 4 patients (50.0%) (NS). PCR analysis of Topo-1 expression revealed high expression in 9 patients (75.0%) from the RG (n=12) and low expression in 3 patients (25.0%), while the N-RG (n=8) showed high expression in all 8 patients (100.0%) and low expression in none (NS). With respect to ERCC-1, PCR analysis revealed high expression in 7 patients (58.3%) from the RG (n=12) and low expression in 5 patients (41.7%), while the N-RG (n=8) showed high expression in 1 patient (12.5%) and low expression in 7 patients (87.5%) (p<0.05). These results suggest that tumor sensitivity to CPT-11 and platinum derivatives is similar in stage II colorectal cancer patients with ONCs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1021-335X
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1045-50
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:17390042-Camptothecin, pubmed-meshheading:17390042-Colorectal Neoplasms, pubmed-meshheading:17390042-DNA Topoisomerases, Type I, pubmed-meshheading:17390042-DNA-Binding Proteins, pubmed-meshheading:17390042-Endonucleases, pubmed-meshheading:17390042-Humans, pubmed-meshheading:17390042-Immunohistochemistry, pubmed-meshheading:17390042-Lymph Nodes, pubmed-meshheading:17390042-Lymphatic Metastasis, pubmed-meshheading:17390042-Neoplasm Recurrence, Local, pubmed-meshheading:17390042-Neoplasm Staging, pubmed-meshheading:17390042-Neoplasms, Unknown Primary, pubmed-meshheading:17390042-Organoplatinum Compounds, pubmed-meshheading:17390042-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:17390042-Topoisomerase I Inhibitors, pubmed-meshheading:17390042-bcl-2-Associated X Protein
pubmed:year
2007
pubmed:articleTitle
Sensitivity to CPT-11 and platinum derivatives of stage II/Dukes' B colorectal cancer with occult neoplastic cells in lymph node sinuses.
pubmed:affiliation
Department of Surgery, Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, Japan. mukai.masaya@hachioji-hosp.tokai.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't