Source:http://linkedlifedata.com/resource/pubmed/id/17387319
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2007-7-26
|
| pubmed:abstractText |
We report results from the PREDICT-Gene case-control study nested in a prospective cohort designed to identify predictors of the onset of depression among adult primary-care attendees. We tested the potential gene-by-environment interaction between 5HTTLPR genotype at the serotonin transporter gene and previous exposure to threatening life events (TLEs) in depression. A total of 737 consecutively recruited participants were genotyped. Additional information was gathered on exposure to TLEs over a 6-month period, socio-demographic data and family history of psychological problems among first-degree relatives. Diagnoses of depression were ascertained using the Composite International Diagnostic Interview (CIDI) by trained interviewers. Two different depressive outcomes were used (ICD-10 depressive episode and ICD-10 severe depressive episode). Both the s/s genotype and exposure to increasing number of TLEs were significantly associated with depression. Moreover, the 5HTTLPR s/s genotype significantly modified the risk conferred by TLEs for both depressive outcomes. Thus, s/s homozygous participants required minimal exposure to TLE (1 TLE) to acquire a level of risk for depression that was only found among l/s or l/l individuals after significantly higher exposure to TLEs (two or more TLEs). The interaction was more apparent when applied to the diagnosis of ICD-10 severe depressive episode and after adjusting for gender, age and family history of psychological problems. Likelihood ratios tests for the interaction were statistically significant for both depressive outcomes (ICD-10 depressive episode: LR X(2)=4.7, P=0.09 (crude), LR-X(2)=6.4, P=0.04 (adjusted); ICD-10 severe depressive episode: LR X(2)=6.9, P=0.032 (crude), LR-X(2)=8.1, P=0.017 (adjusted)).
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
1359-4184
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| pubmed:author |
pubmed-author:BellónJ AJA,
pubmed-author:CervillaJ AJA,
pubmed-author:GutiérrezBB,
pubmed-author:KingMM,
pubmed-author:LorenteJ AJA,
pubmed-author:LunaJ DJD,
pubmed-author:MayoralFF,
pubmed-author:MolinaEE,
pubmed-author:MorenoBB,
pubmed-author:NazarethII,
pubmed-author:PREDICT Study Core Group,
pubmed-author:RiveraMM,
pubmed-author:Torres-GonzálezFF
|
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
748-55
|
| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:17387319-Adolescent,
pubmed-meshheading:17387319-Adult,
pubmed-meshheading:17387319-Aged,
pubmed-meshheading:17387319-Case-Control Studies,
pubmed-meshheading:17387319-Cohort Studies,
pubmed-meshheading:17387319-Depressive Disorder,
pubmed-meshheading:17387319-Family Health,
pubmed-meshheading:17387319-Female,
pubmed-meshheading:17387319-Genetic Linkage,
pubmed-meshheading:17387319-Genetic Predisposition to Disease,
pubmed-meshheading:17387319-Humans,
pubmed-meshheading:17387319-Life Change Events,
pubmed-meshheading:17387319-Logistic Models,
pubmed-meshheading:17387319-Male,
pubmed-meshheading:17387319-Middle Aged,
pubmed-meshheading:17387319-Odds Ratio,
pubmed-meshheading:17387319-Polymorphism, Genetic,
pubmed-meshheading:17387319-Prospective Studies,
pubmed-meshheading:17387319-Psychiatric Status Rating Scales,
pubmed-meshheading:17387319-Risk Factors,
pubmed-meshheading:17387319-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:17387319-Severity of Illness Index,
pubmed-meshheading:17387319-Social Environment,
pubmed-meshheading:17387319-Socioeconomic Factors,
pubmed-meshheading:17387319-Spain,
pubmed-meshheading:17387319-Statistics, Nonparametric
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
The risk for depression conferred by stressful life events is modified by variation at the serotonin transporter 5HTTLPR genotype: evidence from the Spanish PREDICT-Gene cohort.
|
| pubmed:affiliation |
Departamento de Medicina Legal, Toxicología y Psiquiatría, Facultad de Medicina, Universidad de Granada, Granada, Spain. jacb@ugr.es
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|