| pubmed-article:17377064 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17377064 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:17377064 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:17377064 | lifeskim:mentions | umls-concept:C0086376 | lld:lifeskim |
| pubmed-article:17377064 | lifeskim:mentions | umls-concept:C0600388 | lld:lifeskim |
| pubmed-article:17377064 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:17377064 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:17377064 | lifeskim:mentions | umls-concept:C1514758 | lld:lifeskim |
| pubmed-article:17377064 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:17377064 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:17377064 | lifeskim:mentions | umls-concept:C0167464 | lld:lifeskim |
| pubmed-article:17377064 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17377064 | pubmed:dateCreated | 2007-5-25 | lld:pubmed |
| pubmed-article:17377064 | pubmed:abstractText | The 5-hydroxytryptamine(4) (5-HT(4)) receptors have recently emerged as key modulators of learning, memory, and cognitive processes. In neurons, 5-hydroxytryptamine(4) receptors (5-HT(4)Rs) activate cAMP production and protein kinase A (PKA); however, nothing is known about their ability to activate another key signaling pathway involved in learning and memory: the extracellular signal-regulated kinase (ERK) pathway. Here, we show that 5-HT(4)R stimulation, in primary neurons, produced a potent but transient activation of the ERK pathway. Surprisingly, this activation was mostly PKA independent. Similarly, using pharmacological, genetic, and molecular tools, we observed that 5-HT(4)Rs in human embryonic kidney 293 cells, activated the ERK pathway in a G(s)/cAMP/PKA-independent manner. We also demonstrated that other classical G proteins (G(q)/G(i)/G(o)) and associated downstream messengers were not implicated in the 5-HT(4)R-activated ERK pathway. The 5-HT(4)R-mediated ERK activation seemed to be dependent on Src tyrosine kinase and yet totally independent of beta-arrestin. Immunocytofluorescence revealed that ERK activation by 5-HT(4)R was restrained to the plasma membrane, whereas p-Src colocalized with the receptor and carried on even after endocytosis. This phenomenon may result from a tight interaction between 5-HT(4)R and p-Src detected by coimmunoprecipitation. Finally, we confirmed that the main route by which 5-HT(4)Rs activate ERKs in neurons was Src dependent. Thus, in addition to classical cAMP/PKA signaling pathways, 5-HT(4)Rs may use ERK pathways to control memory process. | lld:pubmed |
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| pubmed-article:17377064 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17377064 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17377064 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17377064 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17377064 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17377064 | pubmed:issn | 1059-1524 | lld:pubmed |
| pubmed-article:17377064 | pubmed:author | pubmed-author:DumuisAlineA | lld:pubmed |
| pubmed-article:17377064 | pubmed:author | pubmed-author:ReiterEricE | lld:pubmed |
| pubmed-article:17377064 | pubmed:author | pubmed-author:BockaertJoëlJ | lld:pubmed |
| pubmed-article:17377064 | pubmed:author | pubmed-author:ClaeysenSylvi... | lld:pubmed |
| pubmed-article:17377064 | pubmed:author | pubmed-author:GavenFlorence... | lld:pubmed |
| pubmed-article:17377064 | pubmed:author | pubmed-author:BarthetGaëlG | lld:pubmed |
| pubmed-article:17377064 | pubmed:author | pubmed-author:FrameryBéréni... | lld:pubmed |
| pubmed-article:17377064 | pubmed:author | pubmed-author:PellissierLuc... | lld:pubmed |
| pubmed-article:17377064 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17377064 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:17377064 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17377064 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17377064 | pubmed:pagination | 1979-91 | lld:pubmed |
| pubmed-article:17377064 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:17377064 | pubmed:meshHeading | pubmed-meshheading:17377064... | lld:pubmed |
| pubmed-article:17377064 | pubmed:meshHeading | pubmed-meshheading:17377064... | lld:pubmed |
| pubmed-article:17377064 | pubmed:meshHeading | pubmed-meshheading:17377064... | lld:pubmed |
| pubmed-article:17377064 | pubmed:meshHeading | pubmed-meshheading:17377064... | lld:pubmed |
| pubmed-article:17377064 | pubmed:meshHeading | pubmed-meshheading:17377064... | lld:pubmed |
