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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-3-20
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pubmed:abstractText |
Several lines of laboratory evidence support a role of persistent activation of Akt pathway in oropharyngeal squamous cell carcinoma (OSCC) progression. Loss of phosphatase PTEN is one of the proposed mechanisms of Akt activation. We sought to determine the prognostic significance of Akt activation in a cohort of patients with OSCC as well as the association between phosphorylated (activated) Akt and PTEN levels.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1055-9965
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pubmed:author |
pubmed-author:BurtnessBarbaraB,
pubmed-author:CampRobertR,
pubmed-author:EglestonBrian LBL,
pubmed-author:HafftyBruceB,
pubmed-author:KowalskiDianeD,
pubmed-author:PsyrriAmandaA,
pubmed-author:RimmDavidD,
pubmed-author:SasakiClarenceC,
pubmed-author:SpeierWilliam FWF4th,
pubmed-author:VairaktarisEleftheriosE,
pubmed-author:WeinbergerPaul MPM,
pubmed-author:YuZiweiZ
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
553-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17372251-Adult,
pubmed-meshheading:17372251-Aged,
pubmed-meshheading:17372251-Carcinoma, Squamous Cell,
pubmed-meshheading:17372251-Chi-Square Distribution,
pubmed-meshheading:17372251-Female,
pubmed-meshheading:17372251-Humans,
pubmed-meshheading:17372251-Immunoenzyme Techniques,
pubmed-meshheading:17372251-Male,
pubmed-meshheading:17372251-Middle Aged,
pubmed-meshheading:17372251-Neoplasm Recurrence, Local,
pubmed-meshheading:17372251-Oropharyngeal Neoplasms,
pubmed-meshheading:17372251-PTEN Phosphohydrolase,
pubmed-meshheading:17372251-Phosphorylation,
pubmed-meshheading:17372251-Predictive Value of Tests,
pubmed-meshheading:17372251-Prognosis,
pubmed-meshheading:17372251-Proportional Hazards Models,
pubmed-meshheading:17372251-Protein Array Analysis,
pubmed-meshheading:17372251-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17372251-Survival Analysis,
pubmed-meshheading:17372251-Tumor Markers, Biological
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pubmed:year |
2007
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pubmed:articleTitle |
Phosphorylation of Akt (Ser473) predicts poor clinical outcome in oropharyngeal squamous cell cancer.
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pubmed:affiliation |
Department of Surgery, Yale Cancer Center, P.O. Box 208032, New Haven, CT 06520, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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