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pubmed-article:1737067pubmed:abstractTextWe have identified a hitherto unknown genetic polymorphism of apolipoprotein A-IV (apoA-IV). The molecular basis for this polymorphism is an A to G substitution at nucleotide 1687 resulting in an Asn to Ser change of amino acid 127. The frequencies of the two apoA-IV alleles (designated apoA-IV127Asn and apoA-IV127Ser), determined by Hin c II restriction analysis of PCR amplified exon three of the apoA-IV gene, were 0.788 and 0.212, respectively, in a Finnish population sample. Allele frequencies of another polymorphism due to a Thr to Ser substitution at amino acid 347 were determined using Hinf I restriction analysis. The allele frequencies were 0.823 for apoA-IV347Thr and 0.177 for apoA-IV347Ser. None of the apoA-IV polymorphisms (apoA-IV127:Asn----Ser, apoA-IV347:Thr----Ser and apoA-IV360:Gln----His) had any effect on plasma lipid and lipoprotein concentrations in cohorts of dyslipidemic men and in a population sample of normolipidemic controls. There was also no association between the history of previous myocardial infarction and any of the apoA-IV alleles.lld:pubmed
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pubmed-article:1737067pubmed:articleTitleA novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127.lld:pubmed
pubmed-article:1737067pubmed:affiliationNational Public Health Institute, First Department of Medicine, Helsinki, Finland.lld:pubmed
pubmed-article:1737067pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1737067pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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