Membrane lipids play important roles in signaling reactions. They are involved in most if not all cellular signaling cascades and in a wide variety of tissue and cell types. The purpose of this review is to highlight major pathways of signaling originating in membrane lipids. Details of lipid metabolism, and its relation to protein function, will thus advance understanding of the role of lipids in health and disease.
National University of Singapore, Yong Loo Lin School of Medicine, Department of Biochemistry and Department of Biological Sciences, Centre for Life Sciences, Singapore.
