|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2007-3-26
|
|
pubmed:abstractText |
CFL1 encodes human non-muscle cofilin (n-cofilin), which is an actin-depolymerizing factor and is essential in cytokinesis, endocytosis, and in the development of all embryonic tissues. Cfl1 knockout mice exhibit failure of neural tube closure at E10.5 and die in utero. We hypothesized that genetic variation within the human CFL1 gene may alter the protein's function and result in defective actin depolymerizing and cellular activity during neural tube closure. Such alterations may be associated with an increased risk for neural tube defects (NTDs).
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-10524632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-10525207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-10547847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-10559448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-10791559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-10833330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-12029063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-12649067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-1307234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-15649475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-15939212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-1677062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-16845089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-16924261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-1754501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-2156828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-2691511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-6509022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-8474427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-8800436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352815-9663401
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1471-2350
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
12
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:17352815-California,
pubmed-meshheading:17352815-Case-Control Studies,
pubmed-meshheading:17352815-Cofilin 1,
pubmed-meshheading:17352815-European Continental Ancestry Group,
pubmed-meshheading:17352815-Genotype,
pubmed-meshheading:17352815-Hispanic Americans,
pubmed-meshheading:17352815-Humans,
pubmed-meshheading:17352815-Infant,
pubmed-meshheading:17352815-Infant, Newborn,
pubmed-meshheading:17352815-Polymorphism, Single Nucleotide,
pubmed-meshheading:17352815-Risk Factors,
pubmed-meshheading:17352815-Spinal Dysraphism
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Association between CFL1 gene polymorphisms and spina bifida risk in a California population.
|
|
pubmed:affiliation |
Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas 77030, USA. Hzhu@ibt.tamhsc.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
