Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-5-21
pubmed:abstractText
MicroRNAs are short, noncoding RNAs that play important roles in post-transcriptional gene regulation. Although many functions of microRNAs in plants and animals have been revealed in recent years, the transcriptional mechanism of microRNA genes is not well-understood. To elucidate the transcriptional regulation of microRNA genes, we study and characterize, in a genome scale, the promoters of intergenic microRNA genes in Caenorhabditis elegans, Homo sapiens, Arabidopsis thaliana, and Oryza sativa. We show that most known microRNA genes in these four species have the same type of promoters as protein-coding genes have. To further characterize the promoters of microRNA genes, we developed a novel promoter prediction method, called common query voting (CoVote), which is more effective than available promoter prediction methods. Using this new method, we identify putative core promoters of most known microRNA genes in the four model species. Moreover, we characterize the promoters of microRNA genes in these four species. We discover many significant, characteristic sequence motifs in these core promoters, several of which match or resemble the known cis-acting elements for transcription initiation. Among these motifs, some are conserved across different species while some are specific to microRNA genes of individual species.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-10068441, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-10706289, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-11459855, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-11675008, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-11679670, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-11679671, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-11679672, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-11799393, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-12016061, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-12167709, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-12198168, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-12651739, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-12679032, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-12812784, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-12869753, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-12871707, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-1316192, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-1338774, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-1377279, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-1426767, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-14508493, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-14555699, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-14596907, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-14631048, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-14730017, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-14744438, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-15120907, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-15317971, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-15372072, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-15733318, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-15980501, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-15987809, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-16027132, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-16040653, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-16332710, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-16381981, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-16787547, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-16901935, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-16957364, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-17099701, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-2181446, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-2648571, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-2847030, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-7574496, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-8111031, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-8252621, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-8252622, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-8663263, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-9360980, http://linkedlifedata.com/resource/pubmed/commentcorrection/17352530-9750168
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1553-7358
pubmed:author
pubmed:issnType
Electronic
pubmed:day
9
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e37
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Characterization and identification of microRNA core promoters in four model species.
pubmed:affiliation
Department of Computer Science and Engineering, Washington University in Saint Louis, Saint Louis, Missouri, United States of America.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't