Linked Life Data

17346198

Source:http://linkedlifedata.com/resource/pubmed/id/17346198

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-3-9
pubmed:abstractText
Calprotectin, a protein composed by two subunits of 8 and 14 kD respectively, is released by neutrophils in the biological fluids under inflammatory states. For instance, detection of calprotectin in faeces represents a diagnostic tool in the case of inflammatory bowel disease. Quite interestingly, calprotectin is increased in the stool of healthy newborns from day three up to day thirty and, physiologically, this increase may be interpreted as a defense mechanism against yeast and fungi. Therapeutic attempts at inhibiting the deleterious effect of calprotectin have been experimentally made by using lycoricinidol. This natural compound is able to hamper the calprotectin-induced apoptosis on the one hand. On the other hand, the same compound plays a prophylactic role in the course of experimental arthritis in rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1871-5303
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-5
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Does calprotectin represent a regulatory factor in host defense or a drug target in inflammatory disease?
pubmed:affiliation
Unità Operativa di Neonatologia e Terapia Intensiva Neonatale, Università degli Studi di Bari, Bari, Italia. baldassarre@bioetaev.uniba.it
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't