Linked Life Data

17339997

Source:http://linkedlifedata.com/resource/pubmed/id/17339997

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2007-3-6
pubmed:abstractText
Formation constants of copper(ii), zinc(ii) and calcium(ii) with 3,5-diaminodiamido-4-oxahexacyclododecane (cageL) has been studied by glass electrode potentiometry at 25 degrees C and an ionic strength of 0.15 mol dm(-3). Copper(ii) forms more stable complexes with cageL than zinc(ii) and calcium(ii). Metal ion complexation promotes deprotonation and coordination of the amide nitrogens resulting in overall tetragonal coordination of Cu(2+) suggested by the UV-visible electronic spectra. Speciation calculations using a blood plasma model suggest that zinc(ii) and calcium(ii) are good competitors of copper(ii) in vivo. Bio-distribution experiments using (64)Cu-labelled Cu(ii)-cageL show that about 50% dose of the complex is retained in the body after 24 h.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1477-9226
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1140-9
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Chemical speciation of copper(II) diaminediamide derivative of pentacycloundecane--a potential anti-inflammatory agent.
pubmed:affiliation
Department of Chemistry, University of Cape Town, Private Bag Rondebosch, 7701, South Africa.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't