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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-2-27
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pubmed:abstractText |
We genotyped five polymorphisms, including two polymorphisms with known effects on transcriptional activity, in a large cohort of 427 Alzheimer disease (AD) cases and 472 control subjects. An association between rs463946 (-3102 G/C) and AD was found and was confirmed in a replication sample of a similar size. By contrast, analysis of three recently described rare mutations influencing APP transcription did not confirm their association with AD risk.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1526-632X
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pubmed:author |
pubmed-author:AmouyelPP,
pubmed-author:BriceAA,
pubmed-author:CampionDD,
pubmed-author:CousinEE,
pubmed-author:DeleuzeJ-FJF,
pubmed-author:FrebourgTT,
pubmed-author:GoumidiLL,
pubmed-author:Guyant-MaréchalLL,
pubmed-author:HannequinDD,
pubmed-author:LambertJ-CJC,
pubmed-author:MagaGG,
pubmed-author:PenetCC,
pubmed-author:RauhWW,
pubmed-author:RicardSS,
pubmed-author:Rovelet-LecruxAA
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
684-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17325276-Aged,
pubmed-meshheading:17325276-Alzheimer Disease,
pubmed-meshheading:17325276-Amyloid beta-Protein Precursor,
pubmed-meshheading:17325276-DNA Mutational Analysis,
pubmed-meshheading:17325276-Female,
pubmed-meshheading:17325276-France,
pubmed-meshheading:17325276-Genetic Predisposition to Disease,
pubmed-meshheading:17325276-Genetic Testing,
pubmed-meshheading:17325276-Genetic Variation,
pubmed-meshheading:17325276-Heterozygote,
pubmed-meshheading:17325276-Humans,
pubmed-meshheading:17325276-Incidence,
pubmed-meshheading:17325276-Male,
pubmed-meshheading:17325276-Middle Aged,
pubmed-meshheading:17325276-Polymorphism, Single Nucleotide,
pubmed-meshheading:17325276-Promoter Regions, Genetic,
pubmed-meshheading:17325276-Protease Nexins,
pubmed-meshheading:17325276-Receptors, Cell Surface,
pubmed-meshheading:17325276-Risk Assessment,
pubmed-meshheading:17325276-Risk Factors,
pubmed-meshheading:17325276-Tumor Markers, Biological
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pubmed:year |
2007
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pubmed:articleTitle |
Variations in the APP gene promoter region and risk of Alzheimer disease.
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pubmed:affiliation |
INSERM U614, Faculty of Medicine, IFRMP, 76000 Rouen, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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