Source:http://linkedlifedata.com/resource/pubmed/id/17283861
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2007-2-7
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| pubmed:abstractText |
The contribution of angiotensin I-converting enzyme insertion-deletion polymorphism (ACE I/D) to salt-sensitivity hypertension has been extensively studied by means of salt-loading tests, but whether or not the interaction with daily salt intake affects blood pressure still remains to be clarified. We therefore conducted a cross-sectional study of 284 Japanese male workers (age range, 20-64 years) to examine the effect of ACE I/D genotype and daily salt intake on hypertension. Blood pressure was measured and the ACE I/D was identified by polymerase chain reaction (PCR). Daily salt intake was calculated from a food frequency questionnaire (FFQ). In multivariate analyses, we explored the interaction of ACE I/D and salt intake by means of logistic regression analysis and multiple linear regression analysis. ACE I/D per se was not associated with blood pressure levels or hypertension. ACE I/D interacted with daily salt intake and correlated with hypertension (p for interaction = 0.047). In the ID+II genotype, hypertension was increased by high salt intake (p = 0.005), while in the DD genotype it was not (p = 0.257). The interaction was more prominent in the overweight group (p = 0.039) than in non-overweight group. In the overweight group, high salt intake induced a 10.5 mmHg higher diastolic blood pressure in the ID+II genotype than in the DD genotype (p = 0.042). Our results suggest that ACE I/D and daily salt intake constitute a gene-environment interaction, which may be further modulated by overweight.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0916-9636
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
29
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
751-8
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| pubmed:meshHeading |
pubmed-meshheading:17283861-Adult,
pubmed-meshheading:17283861-Body Mass Index,
pubmed-meshheading:17283861-Gene Deletion,
pubmed-meshheading:17283861-Genetic Predisposition to Disease,
pubmed-meshheading:17283861-Genotype,
pubmed-meshheading:17283861-Humans,
pubmed-meshheading:17283861-Hypertension,
pubmed-meshheading:17283861-Japan,
pubmed-meshheading:17283861-Linear Models,
pubmed-meshheading:17283861-Logistic Models,
pubmed-meshheading:17283861-Male,
pubmed-meshheading:17283861-Middle Aged,
pubmed-meshheading:17283861-Obesity,
pubmed-meshheading:17283861-Peptidyl-Dipeptidase A,
pubmed-meshheading:17283861-Phenotype,
pubmed-meshheading:17283861-Polymorphism, Genetic,
pubmed-meshheading:17283861-Risk Factors,
pubmed-meshheading:17283861-Sodium Chloride, Dietary
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Interaction of angiotensin I-converting enzyme insertion-deletion polymorphism and daily salt intake influences hypertension in Japanese men.
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| pubmed:affiliation |
Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Japan.
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| pubmed:publicationType |
Journal Article
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