Linked Life Data

17253196

Source:http://linkedlifedata.com/resource/pubmed/id/17253196

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-1-26
pubmed:abstractText
The functional maintenance of the vascular endothelial cell barrier depends on different homo- and heterotypic adhesion systems involving tight junctions, junctional adhesion proteins, and cadherins. Upon inflammatory responses, vessel wall-dependent adhesion and transmigration of leukocytes involves the subtle orchestration of intercellular adhesion receptors and their counter-ligands on each cell type. Following tissue injury, the hemostatic/wound-healing process relies on various cell-associated adhesion receptors (particularly integrins) on platelets and vascular cells as well as on extracellular matrix (ECM) proteins to warrant sealing of the wound. In particular, integrin-binding ECM adhesion molecules mediate firm anchorage as well as cellular motility in cooperation with pericellular proteolytic systems. Accumulating evidence indicates that such cell-anchored and ECM adhesion proteins, which are crucial in vascular defense processes, are also expressed in the testicular epithelium and in gametes to mediate the timely events of spermatid movement during spermatogenesis in the testis and to contribute to the various phases of the fertilization process, culminating in sperm-oocyte fusion, respectively. We explore the multifunctional roles of junctional adhesion molecules, nectins, integrins, ECM proteins, and others beyond their role in defense and hemostasis as important contributors in spermatogenesis and sperm function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0094-6176
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
100-10
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The role of multifunctional adhesion molecules in spermatogenesis and sperm function: Lessons from hemostasis and defense?
pubmed:affiliation
Department of Biochemistry, Medical School, Justus-Liebig-University, Giessen, Germany. klaus.t.preissner@biochemie.med.uni-giessen.de
pubmed:publicationType
Journal Article, Review