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rdf:type |
|
|
lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-8-27
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pubmed:abstractText |
Although substantial evidence supports the view that adult neurogenesis is involved in learning and memory, how newly generated neurons contribute to the cognitive process remains unknown. Fibroblast growth factor 2 (FGF-2) is known to stimulate the proliferation of neuronal progenitor cells (NPCs) in adult brain. Using conditional knockout mice that lack brain expression of FGFR1, a major receptor for FGF-2, we have investigated the role of adult neurogenesis in hippocampal synaptic plasticity and learning and memory.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-3223
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
381-90
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17239352-Animals,
pubmed-meshheading:17239352-Behavior, Animal,
pubmed-meshheading:17239352-Bromodeoxyuridine,
pubmed-meshheading:17239352-Cell Count,
pubmed-meshheading:17239352-Cell Proliferation,
pubmed-meshheading:17239352-Dose-Response Relationship, Radiation,
pubmed-meshheading:17239352-Electric Stimulation,
pubmed-meshheading:17239352-Glial Fibrillary Acidic Protein,
pubmed-meshheading:17239352-Hippocampus,
pubmed-meshheading:17239352-Intermediate Filament Proteins,
pubmed-meshheading:17239352-Long-Term Potentiation,
pubmed-meshheading:17239352-Maze Learning,
pubmed-meshheading:17239352-Medial Forebrain Bundle,
pubmed-meshheading:17239352-Memory,
pubmed-meshheading:17239352-Mice,
pubmed-meshheading:17239352-Mice, Transgenic,
pubmed-meshheading:17239352-Mutation,
pubmed-meshheading:17239352-Nerve Tissue Proteins,
pubmed-meshheading:17239352-Neurons,
pubmed-meshheading:17239352-Patch-Clamp Techniques,
pubmed-meshheading:17239352-Phosphopyruvate Hydratase,
pubmed-meshheading:17239352-Reaction Time,
pubmed-meshheading:17239352-Receptor, Fibroblast Growth Factor, Type 1
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pubmed:year |
2007
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|
pubmed:articleTitle |
Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis.
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|
pubmed:affiliation |
Section on Neural Development and Plasticity, Laboratory of Cellular & Synaptic Neurophysiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, N.I.H., Intramural
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