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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-2-23
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pubmed:abstractText |
Linear discriminant analysis was performed to derive discriminant functions based on 2D descriptors and capable of classifying anticonvulsant from non-anticonvulsant compounds. Through application in virtual screening of the discriminant function which performed best in the validation steps, abietic acid was identified as a potential new anticonvulsant agent. The anticonvulsant activity of abietic acid at 30 and 100mg/kg was confirmed in the Maximal Electroshock Test, both orally and intraperitoneally.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1684-90
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17234417-Administration, Oral,
pubmed-meshheading:17234417-Algorithms,
pubmed-meshheading:17234417-Animals,
pubmed-meshheading:17234417-Anticonvulsants,
pubmed-meshheading:17234417-Artificial Intelligence,
pubmed-meshheading:17234417-Computer Simulation,
pubmed-meshheading:17234417-Convulsants,
pubmed-meshheading:17234417-Discriminant Analysis,
pubmed-meshheading:17234417-Diterpenes, Abietane,
pubmed-meshheading:17234417-Drug Evaluation, Preclinical,
pubmed-meshheading:17234417-Electroshock,
pubmed-meshheading:17234417-Injections, Intraperitoneal,
pubmed-meshheading:17234417-Linear Models,
pubmed-meshheading:17234417-Mice,
pubmed-meshheading:17234417-Pentylenetetrazole,
pubmed-meshheading:17234417-Phenanthrenes,
pubmed-meshheading:17234417-Postural Balance,
pubmed-meshheading:17234417-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Discovery of anticonvulsant activity of abietic acid through application of linear discriminant analysis.
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pubmed:affiliation |
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Department of Chemistry, Faculty of Exact Sciences, Universidad Nacional de La Plata, B1900 AVV La Plata, Buenos Aires, Argentina.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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