| pubmed-article:17210721 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17210721 | lifeskim:mentions | umls-concept:C0238463 | lld:lifeskim |
| pubmed-article:17210721 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:17210721 | lifeskim:mentions | umls-concept:C0751984 | lld:lifeskim |
| pubmed-article:17210721 | lifeskim:mentions | umls-concept:C0694890 | lld:lifeskim |
| pubmed-article:17210721 | lifeskim:mentions | umls-concept:C1426113 | lld:lifeskim |
| pubmed-article:17210721 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:17210721 | lifeskim:mentions | umls-concept:C0543431 | lld:lifeskim |
| pubmed-article:17210721 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17210721 | pubmed:dateCreated | 2007-1-9 | lld:pubmed |
| pubmed-article:17210721 | pubmed:abstractText | RET/papillary thyroid carcinoma (PTC) oncoproteins result from the in-frame fusion of the RET receptor tyrosine kinase with protein dimerization motifs encoded by heterologous genes. Here, we show that RET/PTC1 activates the Rap1 small GTPase. The activation of Rap1 was dependent on the phosphorylation of RET Tyr(1062). RET/PTC1 recruited a complex containing growth factor receptor binding protein 2-associated binding protein 1 (Gab1), CrkII (v-crk sarcoma virus CT10 oncogene homologue II), and C3G (Rap guanine nucleotide exchange factor 1). By using dominant-negative and small interfering duplex (small interfering RNA) oligonucleotides, we show that RET/PTC1-mediated Rap1 activation was dependent on CrkII, C3G, and Gab1. Activation of Rap1 was involved in the RET/PTC1-mediated stimulation of the BRAF kinase and the p42/p44 mitogen-activated protein kinases. Proliferation and stress fiber formation of RET/PTC1-expressing PC Cl 3 thyroid follicular cells were inhibited by the dominant-negative Rap1(N17) and by Rap1-specific GTPase-activating protein. Thus, Rap1 is a downstream effector of RET/PTC and may contribute to the transformed phenotype of RET/PTC-expressing thyrocytes. | lld:pubmed |
| pubmed-article:17210721 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17210721 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17210721 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17210721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17210721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17210721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17210721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17210721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17210721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17210721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17210721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17210721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17210721 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17210721 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17210721 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:17210721 | pubmed:author | pubmed-author:FuscoAlfredoA | lld:pubmed |
| pubmed-article:17210721 | pubmed:author | pubmed-author:MelilloRosa... | lld:pubmed |
| pubmed-article:17210721 | pubmed:author | pubmed-author:SantoroMassim... | lld:pubmed |
| pubmed-article:17210721 | pubmed:author | pubmed-author:HershmanJerom... | lld:pubmed |
| pubmed-article:17210721 | pubmed:author | pubmed-author:GuerreroCarme... | lld:pubmed |
| pubmed-article:17210721 | pubmed:author | pubmed-author:CiraficiAnna... | lld:pubmed |
| pubmed-article:17210721 | pubmed:author | pubmed-author:CastelloneMar... | lld:pubmed |
| pubmed-article:17210721 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:17210721 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:17210721 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17210721 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17210721 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:17210721 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17210721 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17210721 | pubmed:pagination | 381-90 | lld:pubmed |
| pubmed-article:17210721 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:17210721 | pubmed:meshHeading | pubmed-meshheading:17210721... | lld:pubmed |
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| pubmed-article:17210721 | pubmed:meshHeading | pubmed-meshheading:17210721... | lld:pubmed |
| pubmed-article:17210721 | pubmed:meshHeading | pubmed-meshheading:17210721... | lld:pubmed |
| pubmed-article:17210721 | pubmed:meshHeading | pubmed-meshheading:17210721... | lld:pubmed |
| pubmed-article:17210721 | pubmed:meshHeading | pubmed-meshheading:17210721... | lld:pubmed |
| pubmed-article:17210721 | pubmed:meshHeading | pubmed-meshheading:17210721... | lld:pubmed |
| pubmed-article:17210721 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17210721 | pubmed:articleTitle | RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase. | lld:pubmed |
| pubmed-article:17210721 | pubmed:affiliation | Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G. Salvatore, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita' Federico II, via Sergio Pansini 5, 8-131 Naples, Italy. | lld:pubmed |
| pubmed-article:17210721 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17210721 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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