Linked Life Data

17201410

Source:http://linkedlifedata.com/resource/pubmed/id/17201410

Statements in which the resource exists.
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pubmed-article:17201410pubmed:abstractText2-Aminopyridine-3,5-dicarbonitrile compounds were previously identified as mimetics of dominant-negative prion protein mutants and inhibit prion replication in cultured cells. Here, we report findings from a comprehensive structure-activity relationship study of the 6-aminopyridine-3,5-dicarbonitrile scaffold. We identify compounds with significantly improved bioactivity (approximately 40-fold) against replication of the infectious prion isoform (PrPSc) and suitable pharmacokinetic profiles to warrant evaluation in animal models of prion disease.lld:pubmed
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pubmed-article:17201410pubmed:articleTitleStructure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.lld:pubmed
pubmed-article:17201410pubmed:affiliationInstitute for Neurodegenerative Diseases, University of California-San Francisco, San Francisco, California 94158, USA. bmay@ind.ucsf.edulld:pubmed
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pubmed-article:17201410pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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