| pubmed-article:17196614 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17196614 | lifeskim:mentions | umls-concept:C1334537 | lld:lifeskim |
| pubmed-article:17196614 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:17196614 | lifeskim:mentions | umls-concept:C1336789 | lld:lifeskim |
| pubmed-article:17196614 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:17196614 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:17196614 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17196614 | pubmed:dateCreated | 2007-2-5 | lld:pubmed |
| pubmed-article:17196614 | pubmed:abstractText | NF-kappaB is an inducible transcription factor activated in many different cell types by inflammatory and stress signals. The transcription of a wide variety of NF-kappaB genes is regulated by the coordinated action of transcription co-activators and co-repressors. Previously we identified Myb binding protein 1a (MYBBP1a) as an interaction partner of the transcription activation domain of RelA/p65. MYBBP1a has been shown by others to regulate various transcription factors, through largely unknown mechanisms. Here we present evidence that MYBBP1a is a novel co-repressor of NF-kappaB. MYBBP1a interacted directly with RelA/p65 and expression of MYBBP1a in cells repressed NF-kappaB dependent reporter expression but did affect neither RelA/p65 nuclear translocation nor its DNA binding activity. In vitro, MYBBP1a inhibited transcription from chromatinized templates at a step before pre-initiation complex formation. MYBBP1a was found to compete with the histone acetyl transferase co-activator, p300, for interaction with the transcription activation domain of RelA/p65. Expression levels of MYBBP1a are dependent on the cell type, and are particularly high in Jurkat T cells. These results indicate that MYBBP1a is a novel NF-kappaB co-repressor of transcription that competes with p300 and may function to regulate cell type specific genes. | lld:pubmed |
| pubmed-article:17196614 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17196614 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17196614 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17196614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17196614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17196614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17196614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17196614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17196614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17196614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17196614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17196614 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17196614 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17196614 | pubmed:issn | 0022-2836 | lld:pubmed |
| pubmed-article:17196614 | pubmed:author | pubmed-author:KrausW LeeWL | lld:pubmed |
| pubmed-article:17196614 | pubmed:author | pubmed-author:CheungEdwinE | lld:pubmed |
| pubmed-article:17196614 | pubmed:author | pubmed-author:HottigerMicha... | lld:pubmed |
| pubmed-article:17196614 | pubmed:author | pubmed-author:OwenHeather... | lld:pubmed |
| pubmed-article:17196614 | pubmed:author | pubmed-author:GersbachMonik... | lld:pubmed |
| pubmed-article:17196614 | pubmed:author | pubmed-author:ElserMichaelM | lld:pubmed |
| pubmed-article:17196614 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17196614 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:17196614 | pubmed:volume | 366 | lld:pubmed |
| pubmed-article:17196614 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17196614 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17196614 | pubmed:pagination | 725-36 | lld:pubmed |
| pubmed-article:17196614 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:17196614 | pubmed:meshHeading | pubmed-meshheading:17196614... | lld:pubmed |
| pubmed-article:17196614 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17196614 | pubmed:articleTitle | MYBBP1a is a novel repressor of NF-kappaB. | lld:pubmed |
| pubmed-article:17196614 | pubmed:affiliation | Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. | lld:pubmed |
| pubmed-article:17196614 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17196614 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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