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rdf:type |
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lifeskim:mentions |
umls-concept:C0003864,
umls-concept:C0087111,
umls-concept:C0591833,
umls-concept:C0871261,
umls-concept:C1150571,
umls-concept:C1524063,
umls-concept:C1537028,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1999216,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2007-1-29
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pubmed:abstractText |
The NF-kappaB signaling pathway promotes the immune response in rheumatoid arthritis (RA) and in rodent models of RA. NF-kappaB activity is regulated by the IKK-2 kinase during inflammatory responses. To elucidate how IKK-2 inhibition suppresses disease development, we used a combination of in vivo imaging, transcription profiling, and histopathology technologies to study mice with antibody-induced arthritis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0004-3591
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pubmed:author |
pubmed-author:AlencarHerlenH,
pubmed-author:ChunMiyoungM,
pubmed-author:HarrimanGeraldineG,
pubmed-author:HealyAileen MAM,
pubmed-author:HepperleMichaelM,
pubmed-author:IzmailovaElena SES,
pubmed-author:JaffeeBruceB,
pubmed-author:LaneJoan HJH,
pubmed-author:MahmoodUmarU,
pubmed-author:OcainTimothyT,
pubmed-author:PazNancyN,
pubmed-author:SchopfLisaL,
pubmed-author:WeisslederRalphR,
pubmed-author:XuYajunY
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
117-28
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17195214-Administration, Oral,
pubmed-meshheading:17195214-Animals,
pubmed-meshheading:17195214-Antirheumatic Agents,
pubmed-meshheading:17195214-Arthritis, Experimental,
pubmed-meshheading:17195214-Arthritis, Rheumatoid,
pubmed-meshheading:17195214-Carbolines,
pubmed-meshheading:17195214-Dose-Response Relationship, Drug,
pubmed-meshheading:17195214-Enzyme Inhibitors,
pubmed-meshheading:17195214-Female,
pubmed-meshheading:17195214-Gene Expression,
pubmed-meshheading:17195214-I-kappa B Kinase,
pubmed-meshheading:17195214-Joints,
pubmed-meshheading:17195214-Mice,
pubmed-meshheading:17195214-Mice, Inbred BALB C,
pubmed-meshheading:17195214-NF-kappa B,
pubmed-meshheading:17195214-Niacinamide,
pubmed-meshheading:17195214-RNA, Messenger,
pubmed-meshheading:17195214-Spectrometry, Fluorescence,
pubmed-meshheading:17195214-Spectroscopy, Near-Infrared,
pubmed-meshheading:17195214-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.
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pubmed:affiliation |
Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA. Elena.Izmailova@mpi.com
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pubmed:publicationType |
Journal Article
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