rdf:type |
|
lifeskim:mentions |
umls-concept:C0006826,
umls-concept:C0030956,
umls-concept:C0147139,
umls-concept:C0220825,
umls-concept:C0335343,
umls-concept:C0596087,
umls-concept:C0920591,
umls-concept:C1280551,
umls-concept:C1311871,
umls-concept:C1704426,
umls-concept:C1709630
|
pubmed:issue |
24
|
pubmed:dateCreated |
2006-12-25
|
pubmed:abstractText |
The angiogenic phenotype of malignant cancers has been established as a target for cancer therapy. ABT-526 and ABT-510, two peptide mimetics of thrombospondin-1 (TSP-1), block angiogenesis in vitro and in vivo and slow tumor growth in mice. To guide the clinical development of these drugs, translational studies in dogs with naturally occurring cancers were initiated.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
1078-0432
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
12
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
7444-55
|
pubmed:dateRevised |
2008-6-5
|
pubmed:meshHeading |
pubmed-meshheading:17189418-Angiogenesis Inhibitors,
pubmed-meshheading:17189418-Animals,
pubmed-meshheading:17189418-Cell Movement,
pubmed-meshheading:17189418-Dogs,
pubmed-meshheading:17189418-Drug Screening Assays, Antitumor,
pubmed-meshheading:17189418-Endothelial Cells,
pubmed-meshheading:17189418-Female,
pubmed-meshheading:17189418-Humans,
pubmed-meshheading:17189418-Male,
pubmed-meshheading:17189418-Neoplasms,
pubmed-meshheading:17189418-Oligopeptides,
pubmed-meshheading:17189418-Peptide Fragments,
pubmed-meshheading:17189418-Thrombospondin 1,
pubmed-meshheading:17189418-Tumor Cells, Cultured
|
pubmed:year |
2006
|
pubmed:articleTitle |
Preclinical evaluation of antiangiogenic thrombospondin-1 peptide mimetics, ABT-526 and ABT-510, in companion dogs with naturally occurring cancers.
|
pubmed:affiliation |
Animal Clinical Investigation, LLC, Columbia, Maryland, USA. trusk@animalci.com
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|