Linked Life Data

17183463

Source:http://linkedlifedata.com/resource/pubmed/id/17183463

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-12-21
pubmed:abstractText
The Pop1/Bves (blood vessel/epicardial substance) gene is a member of the popeye gene family recently identified in various species. It encodes a potential transmembrane glycoprotein and is a cell adhesion molecule present in skeletal and cardiac muscle and epithelia. We isolated the Drosophila homologue of Bves (DmBves) and found, using in situ hybridisation to RNA in ovaries, that bves is expressed in all follicular epithelial cells surrounding the oocyte at stage 10, except those in very posterior and anterior-dorsal regions adjacent to the oocyte. We show that the repression of bves expression in anterior-dorsal follicle cells is regulated by the Grk/EGFR signalling pathway. Bves is also expressed in nurse cells during oogenesis and its transcripts are then translocated into the oocyte. Expression of bves antisense RNA during oogenesis causes reduced viability in the resulting embryos. There is a failure in the migration of pole cells from the posterior towards the antero-dorsal side of the embryo, probably resulting from abnormal germband extension and we suggest that bves is essential for normal embryonic development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0214-6282
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-44
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Blood vessel/epicardial substance (bves) expression, essential for embryonic development, is down regulated by Grk/EFGR signalling.
pubmed:affiliation
Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't