Linked Life Data

17182896

Source:http://linkedlifedata.com/resource/pubmed/id/17182896

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:17182896rdf:typepubmed:Citationlld:pubmed
pubmed-article:17182896lifeskim:mentionsumls-concept:C1123023lld:lifeskim
pubmed-article:17182896lifeskim:mentionsumls-concept:C0078988lld:lifeskim
pubmed-article:17182896lifeskim:mentionsumls-concept:C0239307lld:lifeskim
pubmed-article:17182896lifeskim:mentionsumls-concept:C0023693lld:lifeskim
pubmed-article:17182896lifeskim:mentionsumls-concept:C0314603lld:lifeskim
pubmed-article:17182896lifeskim:mentionsumls-concept:C0015219lld:lifeskim
pubmed-article:17182896lifeskim:mentionsumls-concept:C1707877lld:lifeskim
pubmed-article:17182896lifeskim:mentionsumls-concept:C0332120lld:lifeskim
pubmed-article:17182896pubmed:issue3lld:pubmed
pubmed-article:17182896pubmed:dateCreated2007-3-1lld:pubmed
pubmed-article:17182896pubmed:abstractTextHuman skin pigmentation shows a strong positive correlation with ultraviolet radiation intensity, suggesting that variation in skin color is, at least partially, due to adaptation via natural selection. We investigated the evolution of pigmentation variation by testing for the presence of positive directional selection in 6 pigmentation genes using an empirical F(ST) approach, through an examination of global diversity patterns of these genes in the Centre d'Etude du Polymorphisme Humain (CEPH)-Diversity Panel, and by exploring signatures of selection in data from the International HapMap project. Additionally, we demonstrated a role for MATP in determining normal skin pigmentation variation using admixture mapping methods. Taken together (with the results of previous admixture mapping studies), these results point to the importance of several genes in shaping the pigmentation phenotype and a complex evolutionary history involving strong selection. Polymorphisms in 2 genes, ASIP and OCA2, may play a shared role in shaping light and dark pigmentation across the globe, whereas SLC24A5, MATP, and TYR have a predominant role in the evolution of light skin in Europeans but not in East Asians. These findings support a case for the recent convergent evolution of a lighter pigmentation phenotype in Europeans and East Asians.lld:pubmed
pubmed-article:17182896pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17182896pubmed:languageenglld:pubmed
pubmed-article:17182896pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17182896pubmed:citationSubsetIMlld:pubmed
pubmed-article:17182896pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17182896pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17182896pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17182896pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17182896pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17182896pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17182896pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17182896pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17182896pubmed:statusMEDLINElld:pubmed
pubmed-article:17182896pubmed:monthMarlld:pubmed
pubmed-article:17182896pubmed:issn0737-4038lld:pubmed
pubmed-article:17182896pubmed:authorpubmed-author:ChengKeithKlld:pubmed
pubmed-article:17182896pubmed:authorpubmed-author:KittlesRick...lld:pubmed
pubmed-article:17182896pubmed:authorpubmed-author:ShriverMark...lld:pubmed
pubmed-article:17182896pubmed:authorpubmed-author:CanfieldVicto...lld:pubmed
pubmed-article:17182896pubmed:authorpubmed-author:BradleyDaniel...lld:pubmed
pubmed-article:17182896pubmed:authorpubmed-author:McEvoyBrianBlld:pubmed
pubmed-article:17182896pubmed:authorpubmed-author:NortonHeather...lld:pubmed
pubmed-article:17182896pubmed:authorpubmed-author:ParraEstebanElld:pubmed
pubmed-article:17182896pubmed:authorpubmed-author:McKeiguePaulPlld:pubmed
pubmed-article:17182896pubmed:authorpubmed-author:MaoXianyunXlld:pubmed
pubmed-article:17182896pubmed:issnTypePrintlld:pubmed
pubmed-article:17182896pubmed:volume24lld:pubmed
pubmed-article:17182896pubmed:ownerNLMlld:pubmed
pubmed-article:17182896pubmed:authorsCompleteYlld:pubmed
pubmed-article:17182896pubmed:pagination710-22lld:pubmed
pubmed-article:17182896pubmed:dateRevised2010-11-18lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:meshHeadingpubmed-meshheading:17182896...lld:pubmed
pubmed-article:17182896pubmed:year2007lld:pubmed
pubmed-article:17182896pubmed:articleTitleGenetic evidence for the convergent evolution of light skin in Europeans and East Asians.lld:pubmed
pubmed-article:17182896pubmed:affiliationDepartment of Anthropology, The Pennsylvania State University, PA, USA. hnorton@email.arizona.edulld:pubmed
pubmed-article:17182896pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17182896pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:17182896pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:17182896pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17182896lld:pubmed