Linked Life Data

17159919

Source:http://linkedlifedata.com/resource/pubmed/id/17159919

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-1-4
pubmed:abstractText
The anaphase-promoting complex (APC) early mitotic inhibitor 1 (Emi1) is required to induce S- and M-phase entries by stimulating the accumulation of cyclin A and cyclin B through APC(Cdh1/cdc20) inhibition. In this report, we show that Emi1 proteolysis can be induced by cyclin A/cdk (cdk for cyclin-dependent kinase). Paradoxically, Emi1 is stable during G2 phase, when cyclin A/cdk, Plx1 and SCF(betatrcp) (SCF for Skp1-Cul1-Fbox protein)--which play a role in its degradation--are active. Here, we identify Pin1 as a new regulator of Emi1 that induces Emi1 stabilization by preventing its association with SCF(betatrcp). We show that Pin1 binds to Emi1 and prevents its association with betatrcp in an isomerization-dependent pathway. We also show that Emi1-Pin1 binding is present in vivo in XL2 cells during G2 phase and that this association protects Emi1 from being degraded during this phase of the cell cycle. We propose that S- and M-phase entries are mediated by the accumulation of cyclin A and cyclin B through a Pin1-dependent stabilization of Emi1 during G2.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-10525536, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-10698738, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-11389834, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-11978535, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-11988738, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-12791266, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-12791267, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-14593743, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-15469984, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-15678131, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-15867923, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-16439210, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-16818231, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-8606777, http://linkedlifedata.com/resource/pubmed/commentcorrection/17159919-9395400
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1469-221X
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF(betatrcp).
pubmed:affiliation
Centre de Recherche de Biochimie Macromoléculaire, CNRS FRE 2593, 1919 Route de Mende, 34293 Montpellier cedex 5, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't