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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-12-15
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pubmed:abstractText |
Human homolog of murine double minute 2 (HDM2) and HDM4 (or HDMX) are negative regulators of p53. HDM4 has not been assessed in precursor B (pre-B) lymphoblastic leukemia (ALL). We examined bone marrow samples obtained at time of diagnosis from 55 adults with pre-B ALL. A tissue microarray composed of 2 cores per specimen was constructed and immunohistochemical techniques were used to assess HDM4, HDM2, p53, and p21. HDM4 was expressed in 39 of 49 (80%) cases. HDM2 was expressed in 14 of 54 (26%). All HDM2-positive cases were also positive for HDM4 (P<0.05). We confirmed expression of HDM4 and HDM4 variants by Western blotting and sequencing of reverse transcription-polymerase chain reaction products in a subset of ALL tumors. Results were correlated with the presence of the Philadelphia chromosome (Ph). p53 (P<0.05) and p21 (P<0.001) were expressed significantly more often in Ph+ pre-B ALL. HDM4 and HDM2 showed no correlation with Ph status. HDM4 expression in most cases of adult pre-B ALL suggests that HDM4 is a potential therapeutic target.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/MDM2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MDM4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-mdm2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/TP53 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0893-3952
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pubmed:author |
pubmed-author:BarbozaJuanJ,
pubmed-author:Bueso-RamosCarlos ECE,
pubmed-author:DevV GVG,
pubmed-author:FernandezMichaelM,
pubmed-author:Garcia-ManeroGuillermoG,
pubmed-author:JonesDaniel MDM,
pubmed-author:KantarjianHagop MHM,
pubmed-author:LianchunXiaoX,
pubmed-author:LozanoGuillerminaG,
pubmed-author:McDonnellTimothy JTJ,
pubmed-author:MedeirosL JeffreyLJ,
pubmed-author:NguyenMartinM,
pubmed-author:RassidakisGeorgios ZGZ,
pubmed-author:RosnerGaryG,
pubmed-author:Valentin-VegaYasmine AYA
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
54-62
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17143258-Adolescent,
pubmed-meshheading:17143258-Adult,
pubmed-meshheading:17143258-Aged,
pubmed-meshheading:17143258-Bone Marrow,
pubmed-meshheading:17143258-Cell Line, Tumor,
pubmed-meshheading:17143258-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:17143258-Disease-Free Survival,
pubmed-meshheading:17143258-Female,
pubmed-meshheading:17143258-Follow-Up Studies,
pubmed-meshheading:17143258-Humans,
pubmed-meshheading:17143258-Kaplan-Meier Estimate,
pubmed-meshheading:17143258-Male,
pubmed-meshheading:17143258-Middle Aged,
pubmed-meshheading:17143258-Mutation,
pubmed-meshheading:17143258-Nuclear Proteins,
pubmed-meshheading:17143258-Philadelphia Chromosome,
pubmed-meshheading:17143258-Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:17143258-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:17143258-Prognosis,
pubmed-meshheading:17143258-Proportional Hazards Models,
pubmed-meshheading:17143258-Proto-Oncogene Proteins,
pubmed-meshheading:17143258-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:17143258-RNA, Messenger,
pubmed-meshheading:17143258-Time Factors,
pubmed-meshheading:17143258-Treatment Outcome,
pubmed-meshheading:17143258-Tumor Markers, Biological,
pubmed-meshheading:17143258-Tumor Suppressor Protein p53
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pubmed:year |
2007
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pubmed:articleTitle |
HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target.
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pubmed:affiliation |
Department of Laboratory Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article
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