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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0017262,
umls-concept:C0032659,
umls-concept:C0086418,
umls-concept:C0205265,
umls-concept:C0205314,
umls-concept:C0282491,
umls-concept:C0449435,
umls-concept:C0679622,
umls-concept:C1171362,
umls-concept:C1257890,
umls-concept:C1421876,
umls-concept:C1515670,
umls-concept:C1555582
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pubmed:issue |
6
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pubmed:dateCreated |
2007-3-7
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pubmed:abstractText |
We have identified a novel mature human B-cell subpopulation in the human tonsil that has characteristics of both naive B cells and germinal center B cells including the expression of activation-induced cytidine deaminase (AID), which is essential for the process of immunoglobulin somatic hypermutation and class-switch recombination. These cells are clearly somatically hypermutated, albeit modestly. Their phenotype (IgD(+)CD38(-)CD23(-)FSC(hi)CD71(+)) is unique and suggests they may be intermediate between both naive and germinal center cells. Morphologically they are also distinct from other B-cell subpopulations. The evidence presented suggests these cells may be the founder cells of the germinal center reaction (a pro-GC cell) and may be the normal counterpart of the mantle cell lymphoma cell.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-10326598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-10477711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-10477713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-11007474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-11158612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-11854365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-11861601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-11875397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-12065838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-12071937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-12145648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-12162681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-12205466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-12208878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-12511417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-12586616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-12756266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-12830138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-12873980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-12959216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-14551145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-14769937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-15085198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-15087440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-15117971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-15191950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-15256421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-16157685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-16918701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-2408339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-2438101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-7709838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-7919385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-8006591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-8058704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-8624814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-9373249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17132718-9802980
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2545-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17132718-Antigens, CD38,
pubmed-meshheading:17132718-B-Lymphocytes,
pubmed-meshheading:17132718-Biological Markers,
pubmed-meshheading:17132718-Cell Shape,
pubmed-meshheading:17132718-Coculture Techniques,
pubmed-meshheading:17132718-Cytidine Deaminase,
pubmed-meshheading:17132718-Germinal Center,
pubmed-meshheading:17132718-Humans,
pubmed-meshheading:17132718-Immunoglobulin D,
pubmed-meshheading:17132718-Lymphocyte Count,
pubmed-meshheading:17132718-Mutation,
pubmed-meshheading:17132718-Phenotype,
pubmed-meshheading:17132718-Receptors, IgE,
pubmed-meshheading:17132718-Transcription, Genetic
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pubmed:year |
2007
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pubmed:articleTitle |
A novel human B cell subpopulation representing the initial germinal center population to express AID.
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pubmed:affiliation |
Program in Molecular Immunogenetics, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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